Safety and Efficacy of Multiple Daily Dosing of Oral LFF571 in Patients With Moderate Clostridium Difficile Infections



Status:Completed
Conditions:Infectious Disease
Therapuetic Areas:Immunology / Infectious Diseases
Healthy:No
Age Range:18 - 90
Updated:5/5/2014
Start Date:October 2010
End Date:September 2013
Contact:Novartis Pharmaceuticals
Phone:1-888-669-6682

Use our guide to learn which trials are right for you!

Trial Summary
Trial Overview
Inclusion Criteria

Multi-center, Randomized, Evaluator-blind, Active-controlled,Parallel-group Design to Determine Safety, Tolerability, and Efficacy of Multiple Daily Administration of LFF571 for 10 Days in Patients With Moderate Clostridium Difficile Infections

This study will assess the safety and efficacy of multiple daily dosing of oral LFF571 in
patients who have moderate Clostridium difficile infections.


Inclusion Criteria:

- Males and females between 18 and 90 years of age, inclusive.

- Diagnosed with primary episode or first relapse of moderate C. difficile infection.

Received ≤24 hours of therapy effective for C. difficile infection prior to enrollment.

Exclusion Criteria:

- Severe C. difficile infection

- Expected to require more than 10 days of C. difficile infection treatment.

- More than one prior episode of C. difficile infection within the prior 3 months.

- Use of anti-peristaltic drugs (including tincture of opium, metoclopramide,
loperamide),, cholestyramine, or colestipol

Other protocol-defined inclusion/exclusion criteria may apply
We found this trial at
34
sites
Novartis Investigative Site
Jacksonville, Florida 32216
673
mi
from 43215
Jacksonville, FL
Click here to add this to my saved trials
Novartis Investigative Site
Anderson, Indiana 46016
141
mi
from 43215
Anderson, IN
Click here to add this to my saved trials
Novartis Investigative site
Boston, Massachusetts 02118
643
mi
from 43215
Boston, MA
Click here to add this to my saved trials
Novartis Investigative Site
Bristol, Connecticut 06010
539
mi
from 43215
Bristol, CT
Click here to add this to my saved trials
Novartis Investigative Site
Butte, Montana 59701
1538
mi
from 43215
Butte, MT
Click here to add this to my saved trials
Novartis Investigative Site
Camp Hill, Pennsylvania 17011
323
mi
from 43215
Camp Hill, PA
Click here to add this to my saved trials
Novartis Investigational Site
Charleston, South Carolina 29407
525
mi
from 43215
Charleston, SC
Click here to add this to my saved trials
Novartis Investigator Site
Chicago, Illinois 60612
277
mi
from 43215
Chicago, IL
Click here to add this to my saved trials
Novartis Investigative Site
Cincinnati, Ohio 45229
95
mi
from 43215
Cincinnati, OH
Click here to add this to my saved trials
Novartis Investigator Site
Clearwater, Florida 33756
830
mi
from 43215
Clearwater, FL
Click here to add this to my saved trials
Novartis Investigative Site
Columbus, Ohio 43205
3
mi
from 43215
Columbus, OH
Click here to add this to my saved trials
Novartis Investigative Site
Danbury, Connecticut 06810
510
mi
from 43215
Danbury, CT
Click here to add this to my saved trials
Novartis Investigative Site
Danbury, Connecticut 06810
510
mi
from 43215
Danbury, CT
Click here to add this to my saved trials
Novartis Investigative Site
Decatur, Georgia 30030
433
mi
from 43215
Decatur, GA
Click here to add this to my saved trials
Novartis
Denver, Colorado 80262
1159
mi
from 43215
Denver, CO
Click here to add this to my saved trials
Novartis Investigative Site
Durham, North Carolina 27710
352
mi
from 43215
Durham, NC
Click here to add this to my saved trials
Novartis Investigative Site
Hagerstown, Maryland 21742
282
mi
from 43215
Hagerstown, MD
Click here to add this to my saved trials
Novartis Investigative Site
Hartford, Connecticut 06106
554
mi
from 43215
Hartford, CT
Click here to add this to my saved trials
Novartis Investigative Site
Houston, Texas 77030
995
mi
from 43215
Houston, TX
Click here to add this to my saved trials
Novartis Investigative Site
Idaho Falls, Idaho 83404
1507
mi
from 43215
Idaho Falls, ID
Click here to add this to my saved trials
Novartis Investigative Site
Jacksonville, North Carolina 28546
473
mi
from 43215
Jacksonville, NC
Click here to add this to my saved trials
Novartis Investigative Site
Kalamazoo, Michigan 49048
208
mi
from 43215
Kalamazoo, MI
Click here to add this to my saved trials
Novartis Investigative Site
Knoxville, Tennessee 37934
280
mi
from 43215
Knoxville, TN
Click here to add this to my saved trials
Novartis Investigative site
Los Angeles, California 90095
1982
mi
from 43215
Los Angeles, CA
Click here to add this to my saved trials
Novartis Investigative Site
Michigan City, Indiana 46360
235
mi
from 43215
Michigan City, IN
Click here to add this to my saved trials
Novartis Investigative Site
Mineola, New York 11501
496
mi
from 43215
Mineola, NY
Click here to add this to my saved trials
Novartis Investigative Site
Newark, Delaware 19713
385
mi
from 43215
Newark, DE
Click here to add this to my saved trials
Novartis Investigative Site
Ogden, Utah 84405
1515
mi
from 43215
Ogden, UT
Click here to add this to my saved trials
Novartis Investigative Site
Oklahoma City, Oklahoma 73104
848
mi
from 43215
Oklahoma City, OK
Click here to add this to my saved trials
Novartis Investigative Site
Palm Desert, California 92211
1882
mi
from 43215
Palm Desert, CA
Click here to add this to my saved trials
Novartis
San Antonio, Texas 78207
Novartis Novartis, which was created in 1996 by the merger of the Swiss companies Ciba-Geigy...
1139
mi
from 43215
San Antonio, TX
Click here to add this to my saved trials
Novartis Investigator Site
Topeka, Kansas 66606
678
mi
from 43215
Topeka, KS
Click here to add this to my saved trials
Novartis Investigative Site
Troy, Michigan 48098
181
mi
from 43215
Troy, MI
Click here to add this to my saved trials
Novartis Investigative Site
West Reading, Pennsylvania 19611
374
mi
from 43215
West Reading, PA
Click here to add this to my saved trials