A Study of FolateScan in Patients With Knee Osteoarthritis

The purpose of this study is to evaluate 99mTc - EC20 imaging (FolateScan), a Nuclear
Medicine imaging technology that enables localization of activated macrophages in the joints
of participants with knee osteoarthritis (OA). Twenty five participants with symptomatic
unilateral or bilateral knee OA will undergo a one-time evaluation of the knee as follows:
knee radiography, FolateScan of the knees and whole body, musculoskeletal exam,
questionnaires, sampling of blood, urine and synovial fluid for analysis of inflammatory
markers. Data analysis will be cross-sectional and include a comparison of the location and
intensity of EC20 uptake with the following: radiographic knee OA severity, clinical
measures of disease severity, cytokine expression, and synovial fluid cell count.