Assessing Response to Albuterol in Bronchiolitis
| Status: | Recruiting |
|---|---|
| Conditions: | Bronchitis |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | Any - 2 |
| Updated: | 4/21/2016 |
| Start Date: | November 2010 |
| End Date: | April 2018 |
| Contact: | Christopher L Carroll, MD, MS |
| Email: | ccarrol@ccmckids.org |
| Phone: | 860-545-9805 |
Bronchiolitis is a significant cause of morbidity and hospitalizations in children,
accounting for more than 125,000 hospitalized children per year in the United States.
Although treatment is largely supportive, bronchodilator medications such as albuterol are
frequently used due to increased pulmonary resistance in this population.2-4 However,
despite four decades of clinical trials, the efficacy of albuterol in the treatment of
bronchiolitis has yet to be proven. This inconsistency is due in part to the lack of
sufficiently sensitive methods for the evaluation of lung function and thus the response to
albuterol in infants. Because of the difficulties in evaluating the response to therapy,
healthcare providers are forced to rely on their physical examination skills or a clinical
scoring system, both of which are highly subjective in this population. The investigators
propose to conduct a prospective observational study of healthcare providers to determine
the accuracy of clinical assessment as compared to that of pulmonary mechanics in a
population of children intubated and mechanically ventilated for bronchiolitis.
accounting for more than 125,000 hospitalized children per year in the United States.
Although treatment is largely supportive, bronchodilator medications such as albuterol are
frequently used due to increased pulmonary resistance in this population.2-4 However,
despite four decades of clinical trials, the efficacy of albuterol in the treatment of
bronchiolitis has yet to be proven. This inconsistency is due in part to the lack of
sufficiently sensitive methods for the evaluation of lung function and thus the response to
albuterol in infants. Because of the difficulties in evaluating the response to therapy,
healthcare providers are forced to rely on their physical examination skills or a clinical
scoring system, both of which are highly subjective in this population. The investigators
propose to conduct a prospective observational study of healthcare providers to determine
the accuracy of clinical assessment as compared to that of pulmonary mechanics in a
population of children intubated and mechanically ventilated for bronchiolitis.
Inclusion Criteria:
- Hospitalization with a primary admission diagnosis of bronchiolitis
- Age between birth and 2 years
- Intubated with < 1 cm H2O leak around endotracheal tube
- Receiving inhaled albuterol therapy
Exclusion Criteria:
- Not meeting inclusion criteria
We found this trial at
1
site
282 Washington St
Hartford, Connecticut 06106
Hartford, Connecticut 06106
(860) 545-9000
Phone: 860-545-9805
Connecticut Children's Medical Center Connecticut Children’s Medical Center is a nationally recognized, 187-bed not-for-profit children’s...
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