Investigations of Botanicals on Food Intake, Satiety, Weight Loss, and Oxidative Stress

Despite widespread efforts to improve the treatment of obesity, only limited progress has
been made. Calorie restriction (CR) has consistently been shown to produce weight loss, as
well as delay the onset of age-related diseases, in numerous species. Most overweight
individuals, however, are unable to sustain CR induced weight losses, possibly due to
internal feedback systems that signal the body to increase food intake or decrease energy
expenditure in response to weight loss. Novel treatment approaches are thus urgently needed
that can assist overweight individuals in adhering to a CR regimen over the long-term.

Botanicals represent an important and underexplored source of potential new therapies that
may facilitate CR. In particular, one promising botanical that may reduce food intake and
body weight by affecting neuroendocrine pathways related to satiety is Garcinia Cambogia
(Garcinia Cambogia Desr.)-derived (-)-hydroxycitric acid. This compound has been found to
facilitate weight loss in a number of studies. To date, few studies have directly tested
the effect that this botanical on food intake in humans, its mechanism of action, or its
effect on oxidative stress levels; thus rigorous scientific studies on this compounds need
to be conducted. A double-blind, placebo-controlled crossover study will be conducted to
explore the role that two different doses of this botanical compound have on food intake,
satiety, weight loss, and oxidative stress levels. It is hypothesized that compared to
placebo, both doses of Garcinia Cambogia (hydroxycitric acid) will reduce food intake,
increase satiety, decrease weight, and reduce oxidative stress levels.