Safety and Pharmacokinetics Study With AB0024 in Patients With Idiopathic Pulmonary Fibrosis.



Status:Completed
Conditions:Pulmonary
Therapuetic Areas:Pulmonary / Respiratory Diseases
Healthy:No
Age Range:40 - 85
Updated:11/23/2013
Start Date:December 2010
End Date:March 2012

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A Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AB0024 in Adult Patients With Idiopathic Pulmonary Fibrosis.


The purpose of this phase I, dose escalation study is to evaluate AB0024 in patients with
Idiopathic Pulmonary Fibrosis.


Inclusion Criteria:

- Acceptable results on pulmonary function tests

- At rest oxygen saturation ≥90% on room air

- Adequate organ function

Exclusion Criteria:

- High resolution computer tomography pattern showing emphysema that is greater than
fibrosis

- Acceptable results on whole body plethysmography

- History of clinically significant hepatic or renal disease

- Poorly controlled or severe diabetes mellitus

- Use of systemic immunosuppressants within 28 days of AB0024 infusion
We found this trial at
5
sites
1211 Medical Center Dr
Nashville, Tennessee 37232
(615) 322-5000
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
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171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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Charleston, SC
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10833 Le Conte Ave
Los Angeles, California 90095
(310) 825-4321
David Geffen School of Medicine, UCLA In 2002 Mr. David Geffen announced a $200 million...
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Los Angeles, CA
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Pittsburg, Pennsylvania 15213
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Pittsburg, PA
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300 Pasteur Dr
Stanford, California 94305
(650) 723-4000
Stanford Univ Med Ctr The Medical Center is uniquely advantaged by its location on the...
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Stanford, CA
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