Open Label Study With Imetelstat to Determine Effect of Imetelstat in Patients w/ Previously Treated Multiple Myeloma

Inclusion Criteria:

Willing and able to sign an informed consent Male or female, 18 years or older Confirmed
diagnosis of multiple myeloma (secretory disease) by International Myeloma Working Group
Diagnostic Criteria

Patients must meet one of the following criteria:

o Previously treated patients with multiple myeloma who achieved at least stable disease
but who have failed to achieve a complete response (CR) after a minimum of one
cytoreductive therapy for multiple myeloma and have detectable but non-progressing
disease. Patients must have received at least one proteasome inhibitor (eg, bortezomib) or
one immunomodulatory agent (eg, thalidomide or lenalidomide) or both.

Patients receiving lenalidomide as maintenance therapy may continue to receive this
therapy provided that the patient has been on this maintenance therapy for a minimum of 3
months and has evidence of disease stabilization.

Disease stabilization will be defined as an M protein that varies ≤ 25% over the three
measurements or remains under 0.5 g/dL whichever is smaller.

ECOG performance status 0-2 Life expectancy ≥ 3 months

Laboratory criteria (within 14 days of first study drug administration):

- ANC ≥ 1000/μL

- Platelet count ≥ 50 x 103/μL (without transfusion support within 2 weeks prior to
first study drug administration)

- Hemoglobin ≥ 8.0 g/dL

- Serum creatinine ≤ 3 x the upper limit of normal (ULN)

- AST (SGOT) and ALT (SGPT) ≤ 2.5 x the upper limit of normal (ULN), unless due to
disease.

Must have fully recovered from any previous cancer treatments and/or major surgery.

Women of childbearing potential must have a negative serum pregnancy test and agree to use
effective birth control (two reliable forms of contraception) during and for at least 12
weeks after the last treatment.

Males must agree to use effective birth control for themselves or their partner during and
for 12 weeks after the last treatment with imetelstat. For those patients receiving
lenolidomide, males must use latex condom during sexual contact with women of childbearing
potential even if they have undergone a successful vasectomy.

Exclusion Criteria:

Women who are pregnant or breast feeding Prior radioimmunotherapy. Known intracranial
disease or epidural disease. Patients with lytic lesions of the cranium or spine secondary
to myeloma are eligible to enroll.

Clinically significant cardiovascular disease or condition including:

- Congestive heart failure (CHF) requiring therapy

- Need for antiarrhythmic therapy for a ventricular arrhythmia

- Severe conduction disturbance

- Angina pectoris requiring therapy

- Uncontrolled hypertension per the Investigator's discretion

- New York Heart Association Class II, III, or IV cardiovascular disease Active or
chronically recurrent bleeding (eg, active peptic ulcer disease) Clinically relevant
active infection. Serious co-morbid medical conditions, including cirrhosis and
chronic obstructive or chronic restrictive pulmonary disease.

Symptomatic hyperviscosity syndrome. Any other cancer therapy including chemotherapy,
monoclonal antibody, signal transduction inhibitor, immunotherapy, glucocorticoid (except
topical or as premedication), thalidomide within 3 weeks prior to first study drug
administration.

Investigational therapy within 4 weeks prior to first study drug administration.

Major surgery within 4 weeks prior to first study drug administration (central line
placement is allowed) Anti-platelet therapy within 2 weeks prior to first study drug
administration, other than low dose aspirin prophylaxis therapy.

Full dose anticoagulation. Prophylactic low dose administration for management of IV
access devices is allowed.

Known positive serology for human immunodeficiency virus (HIV. Any other severe, acute, or
chronic medical or psychiatric condition, laboratory abnormality, or difficulty complying
with protocol requirements that may increase the risk associated with study participation
or study drug administration or may interfere with the interpretation of study results
and, in the judgment of the investigator, would make the patient inappropriate for this
study