Optical Coherence Tomography Guided Transepithelial Phototherapeutic Keratectomy
| Status: | Recruiting |
|---|---|
| Conditions: | Ocular |
| Therapuetic Areas: | Ophthalmology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/17/2018 |
| Start Date: | June 2011 |
| End Date: | December 2022 |
| Contact: | Omkar Thaware, B Optom, MSVS |
| Email: | thaware@ohsu.edu |
| Phone: | 503-494-7398 |
Optical Coherence Tomography (OCT) machines are non-contact instruments that can measure the
depth of scars and other causes of cloudiness in the front of the cornea. The purpose of this
study is to determine whether OCT-guided settings for the lasers used for removal of corneal
scars and other partial-thickness corneal defects result in improved vision in patients
receiving these procedures.
depth of scars and other causes of cloudiness in the front of the cornea. The purpose of this
study is to determine whether OCT-guided settings for the lasers used for removal of corneal
scars and other partial-thickness corneal defects result in improved vision in patients
receiving these procedures.
The long-term goal of this project is to utilize newly available very high-speed OCT
technology to guide surgical treatments of corneas with superficial opacities and
irregularities. OCT is well known for its exquisite resolution, but until recently it has not
had sufficient speed to capture the shape of the cornea because of eye motion during OCT
scanning. The development of Fourier-domain OCT (FD-OCT) technology has made the requisite
speed possible.
Eyes with superficial opacities (corneal scars and stromal dystrophies) can be treated by
phototherapeutic keratectomy (PTK). Currently, many surgeons rely on subjective slit-lamp
impression of opacity depth to guide PTK and repeat slit-lamp examinations during surgery to
determine if the opacity has been sufficiently reduced. Unpredictable hyperopic shifts can
occur after PTK. The aim of this project is to develop methods for imaging the cornea with an
FD-OCT system that will precisely measure corneal shape and use this information to guide
surgery. Patients with irregularly shaped corneas could have their vision restored by
reshaping the corneas with a procedure that combines the precision of OCT and lasers.
technology to guide surgical treatments of corneas with superficial opacities and
irregularities. OCT is well known for its exquisite resolution, but until recently it has not
had sufficient speed to capture the shape of the cornea because of eye motion during OCT
scanning. The development of Fourier-domain OCT (FD-OCT) technology has made the requisite
speed possible.
Eyes with superficial opacities (corneal scars and stromal dystrophies) can be treated by
phototherapeutic keratectomy (PTK). Currently, many surgeons rely on subjective slit-lamp
impression of opacity depth to guide PTK and repeat slit-lamp examinations during surgery to
determine if the opacity has been sufficiently reduced. Unpredictable hyperopic shifts can
occur after PTK. The aim of this project is to develop methods for imaging the cornea with an
FD-OCT system that will precisely measure corneal shape and use this information to guide
surgery. Patients with irregularly shaped corneas could have their vision restored by
reshaping the corneas with a procedure that combines the precision of OCT and lasers.
Inclusion Criteria:
- Patients with vision primarily limited by superficial opacities and irregularities
that could be removed by PTK while leaving at least 250 µm.
Exclusion Criteria:
- Inability to give informed consent
- Inability to maintain stable fixation for OCT imaging
- Inability to commit to required visits to complete the study
- Deep corneal opacities and irregularities
- Cataracts, retinal disease, glaucoma, or other eye conditions that may limit the
visual outcome after surgery
We found this trial at
1
site
Portland, Oregon 97239
Principal Investigator: David Huang, MD, PhD
Phone: 503-494-7398
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