3-D Transcranial Ultrasound Analysis Study
| Status: | Completed |
|---|---|
| Conditions: | High Blood Pressure (Hypertension), Neurology |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Neurology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 5/3/2014 |
| Start Date: | May 2006 |
| End Date: | December 2013 |
| Contact: | Ellen R Bennett, PhD |
| Email: | ellen.bennett@duke.edu |
| Phone: | (919)668-1429 |
3-D Transcranial Ultrasound Analysis Using Definity Injectable Suspension
The purpose of this study is to investigate real time 3-D ultrasound imaging of the brain
for the diagnosis and evaluation of stroke.
for the diagnosis and evaluation of stroke.
The objective of this proposal is to extend our previous advances to investigate real time
3-D ultrasound imaging of the brain for the diagnosis and evaluation of stroke. Over the
last decade, with the availability of color flow Doppler combined with effective ultrasound
contrast agents, a renaissance has occurred in transcranial sonography as a low cost,
bedside method for evaluation and management of patients with cerebrovascular disease in
spite of the image degrading properties of the skull. Our hypothesis is that we can combine
new generations of 2D array transducers with ultrasound contrast agents and phase aberration
correction to enable real time 3D ultrasound imaging and 3D color flow Doppler of the brain
with a factor of 10 improvement in spatial resolution compared to conventional transcranial
sonography for improved diagnosis and evaluation of stroke.
3-D ultrasound imaging of the brain for the diagnosis and evaluation of stroke. Over the
last decade, with the availability of color flow Doppler combined with effective ultrasound
contrast agents, a renaissance has occurred in transcranial sonography as a low cost,
bedside method for evaluation and management of patients with cerebrovascular disease in
spite of the image degrading properties of the skull. Our hypothesis is that we can combine
new generations of 2D array transducers with ultrasound contrast agents and phase aberration
correction to enable real time 3D ultrasound imaging and 3D color flow Doppler of the brain
with a factor of 10 improvement in spatial resolution compared to conventional transcranial
sonography for improved diagnosis and evaluation of stroke.
Inclusion Criteria:
Exclusion Criteria:
- persons <18 years old
- pregnant or nursing women
- history of neurological disease
- congenital heart defect
- severe liver dysfunction
- respiratory distress syndrome
- hypersensitivity or an allergic reaction to blood products.
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