Early Treatment With Dexamethasone in Mild Acute Pancreatitis



Status:Completed
Conditions:Gastrointestinal
Therapuetic Areas:Gastroenterology
Healthy:No
Age Range:18 - 75
Updated:4/2/2016
Start Date:November 2010
End Date:July 2012
Contact:Bechien U Wu
Email:buwu@partners.org

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Trial Summary
Trial Overview
Inclusion Criteria

Intravenous Dexamethasone for the Early Treatment of Mild Acute Pancreatitis: A Double-Blind, Randomized, Placebo Controlled Trial

This pilot trial will evaluate the following in patients with acute pancreatitis:

1. Safety profile of early treatment with intravenous dexamethasone

2. Impact of dexamethasone on systemic inflammation in patients with acute pancreatitis

3. Provide preliminary data on potential impact of early treatment with steroids on
clinical outcomes


Inclusion Criteria:

- Age>=18 years

- Diagnosis of acute pancreatitis confirmed by at least 2 of the following:

1. Typical epigastric abdominal pain

2. Elevation amylase/lipase >3 times upper limit normal and/or

3. Confirmatory findings on cross-sectional imaging

- Enrollment within 8 hours of presentation

Exclusion Criteria:

- Class II or greater NYHA heart failure

- Oxygen dependent COPD

- Chronic kidney disease>stage 2

- Cirrhosis

- Existing necrosis on abdominal CT

- Organ dysfunction prior to enrollment

- Sepsis

- Acute respiratory distress syndrome

- Malignancy not in remission for at least 5 years

- Active drug use

- Known allergy to dexamethasone

- Altered mental status

- Insulin-requiring diabetes

- Abdominal surgery within 60 days
We found this trial at
1
site
Brigham and Women's Hosp
75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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from
Boston, MA
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