Comparison of Transfers of Thawed Blastocysts Versus Blastocysts Derived From Thawed Bipronuclear Oocytes
| Status: | Completed |
|---|---|
| Conditions: | Women's Studies, Infertility |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | 18 - 40 |
| Updated: | 2/7/2015 |
| Start Date: | December 2010 |
| End Date: | December 2014 |
| Contact: | Bruce Shapiro, M.D., Ph.D. |
| Phone: | (702) 254-1777 |
The purpose of this study is to determine if cryopreservation at the blastocyst stage
followed by embryo thaw and transfer is as effective as cryopreservation of bipronuclear
oocytes followed by post-thaw extended culture (PTEC), and blastocyst transfer.
Effectiveness will be measured by the rate of ongoing pregnancy at 10 weeks gestation.
followed by embryo thaw and transfer is as effective as cryopreservation of bipronuclear
oocytes followed by post-thaw extended culture (PTEC), and blastocyst transfer.
Effectiveness will be measured by the rate of ongoing pregnancy at 10 weeks gestation.
Subjects will be randomized to one of two study groups during their cycles of in vitro
fertilization (IVF). In one group, the subjects will have all of their embryos
cryopreserved at the blastocyst stage, followed by thaw and transfer in a subsequent cycle.
In the other group, subjects will have all of their embryos cryopreserved at the
bipronuclear oocyte stage, followed by thaw, extended culture, and transfer in a subsequent
cycle.
fertilization (IVF). In one group, the subjects will have all of their embryos
cryopreserved at the blastocyst stage, followed by thaw and transfer in a subsequent cycle.
In the other group, subjects will have all of their embryos cryopreserved at the
bipronuclear oocyte stage, followed by thaw, extended culture, and transfer in a subsequent
cycle.
Inclusion Criteria:
1. Female patient seeking autologous in vitro fertilization (IVF) treatment.
2. Cycle day 3 serum concentration of follicle stimulating hormone (FSH) less than 10.0
IU/l.
3. Baseline total antral follicle count observed on ultrasound with at least eight
antral follicles.
4. 18 to 40 years of age.
5. Ability to read and understand English.
Exclusion Criteria:
1. Embryo biopsy (a.k.a. pre-implantation genetic diagnosis (PGD)).
2. Any condition that, in the opinion of the physician or principal investigator, would
place the patient at undue risk under this protocol or would otherwise make the
protocol inappropriate for that subject.
3. No minors will be enrolled in this study.
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