Bimodal Analgesia as Form of Pain Control Post Long Bone Fracture

This will be a prospective, randomized, control trial looking at the benefit of bimodal
analgesia in the treatment of long bone fractures. The traditional pain control regimen
following fracture fixation typically involves a course of narcotics on an as-needed basis
for pain relief. Recent data has shown that adding NSAIDS to the pain regimen as part of a
bimodal approach to pain control, improves the efficacy of pain management and reduces
narcotic use. Laboratory research on NSAIDs as it pertains to bone healing, however, has
shown in animal models that there may be a positive association between NSAIDS and non-union
rates. In other words, NSAIDS may prevent or delay bone healing. These results, however,
have not been tested prospectively in humans.

The purpose of this study is to look at the combination of NSAIDS and narcotics post long
bone fracture and monitor the effects on narcotic use and healing rates to ultimately and
conclusively establish the risk or benefit of NSAIDS after long bone fracture.

Inclusion Criteria:

- skeletally mature patients over the age of 18 years

- Fracture of Tibia, femur, or Humerus.

Exclusion Criteria:

- Open fractures grade III

- Open fractures with suspected compartment syndrome

- history of prior fracture in particular limb.

- Concurrent usage of Steroid drugs, and immunosuppressants.

- Prior or current history of GI bleeding.