Human Cytochrome P450 4F Enzymes and Drug Interactions

Drug-drug interactions play an important role in clinical adverse events due to the
prevalence of multi-drug therapy. Co-administration of warfarin and a statin has expanded
substantially in the US over the last decades. The purpose of this study is to develop a
mechanistic understanding of the role of a drug-metabolizing enzyme, CYP4F2, in the
interaction between warfarin and statins. This study will test the hypothesis that
lovastatin potentiates the anticoagulant effect of warfarin by inducing vitamin
K-metabolizing enzyme CYP4F2 in humans, thus increasing warfarin's anticoagulant effect.