Imaging With a Radio Tracer to Guide VT Ablations
| Status: | Completed |
|---|---|
| Conditions: | Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/17/2018 |
| Start Date: | March 2010 |
| End Date: | August 2015 |
Three Dimension Neuron Imaging Using 123I-metaiodobenzylguanidine Single Photon Emission Computed Tomography to Guide Ventricular Tachycardia Ablations
Some patients are at risk for life-threatening fast heart rates. These can frequently be
treated by using a catheter inside the heart to burn away the cells that create the fast
heart rates. The purpose of this study is to image the nerves inside the heart of those
patients. The investigators want to find out if abnormalities in the nervous system in the
heart can help the physician to find the area that needs to be burnt away.
treated by using a catheter inside the heart to burn away the cells that create the fast
heart rates. The purpose of this study is to image the nerves inside the heart of those
patients. The investigators want to find out if abnormalities in the nervous system in the
heart can help the physician to find the area that needs to be burnt away.
Ventricular tachycardia is the next frontier in cardiology. Patients that have scar in the
heart (for example after heart attacks) are at an increased risk of developing ventricular
tachycardia. In these patients ventricular tachycardia represents an electrical wave front
that circulates in the heart muscle using the scar in the heart. An increasing number of
patients with ventricular tachycardia require cauterization (burning away) of the tissue to
treat this life-threatening condition. The goal of this cauterization or ablation is to
destroy "highways of surviving tissue" inside the scar, that allow ventricular tachycardia to
exist. However, this can be very lengthy procedure (>5 hours) that has only a moderate
success in the long run. Therefore, new treatment approaches are needed to make this
procedure better.
The purpose of this study is to assess if radio tracers showing the nerve distribution in the
heart (cardiac innervation) can be used in addition to the current technology ("voltage
mapping") to identify the area that needs to be ablated (burnt away) to treat
life-threatening fast heart rates (ventricular tachycardia)
Certain patterns of nerve distribution in the heart (sympathetic cardiac innervation) have
been shown to predict outcome for different heart diseases, like heart transplant, coronary
artery disease, heart failure, arrhythmias. One substance that allows visualization of the
cardiac innervation is 123I-metaiodobenzylguanidine (123I-MIBG), which could provide
additional information to understand and treat ventricular tachycardia.
heart (for example after heart attacks) are at an increased risk of developing ventricular
tachycardia. In these patients ventricular tachycardia represents an electrical wave front
that circulates in the heart muscle using the scar in the heart. An increasing number of
patients with ventricular tachycardia require cauterization (burning away) of the tissue to
treat this life-threatening condition. The goal of this cauterization or ablation is to
destroy "highways of surviving tissue" inside the scar, that allow ventricular tachycardia to
exist. However, this can be very lengthy procedure (>5 hours) that has only a moderate
success in the long run. Therefore, new treatment approaches are needed to make this
procedure better.
The purpose of this study is to assess if radio tracers showing the nerve distribution in the
heart (cardiac innervation) can be used in addition to the current technology ("voltage
mapping") to identify the area that needs to be ablated (burnt away) to treat
life-threatening fast heart rates (ventricular tachycardia)
Certain patterns of nerve distribution in the heart (sympathetic cardiac innervation) have
been shown to predict outcome for different heart diseases, like heart transplant, coronary
artery disease, heart failure, arrhythmias. One substance that allows visualization of the
cardiac innervation is 123I-metaiodobenzylguanidine (123I-MIBG), which could provide
additional information to understand and treat ventricular tachycardia.
Inclusion Criteria:
- Patients with ventricular arrhythmias requiring VT Ablation
- Patients must be 18 years of age or older
- Patient must be able to sign consent form
- Patient must be willing to come back for the 6 month visit for additional study
procedures
Exclusion Criteria:
- Patient under 18 years old
- Inability to sign consent
- Pregnant Women
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