Effect of Niacin on Transport of HDL and Relationship to Atherogenic Lipoproteins and Lipolysis
| Status: | Archived |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | November 2010 |
| End Date: | April 2011 |
A Randomized, Double-Blind, Placebo Controlled Study Evaluating the Effects Of Niacin On Reverse Cholesterol Transport As Measured Using 3H Particulate Cholesterol in Healthy Volunteers
This study looks at whether niacin improves reverse cholesterol transport (RCT) in healthy
volunteers. 3H-Cholesterol will be used to measure RCT by analyzing changes in the tracer
activity in total plasma, lipoproteins, red blood cells (RBCs) and stool. The hypothesis is
that niacin augments reverse cholesterol transport.
The study will use 3H-cholesterol bound to albumin (particulate cholesterol) to assess the
ability of high density lipoprotein (HDL) to transport cholesterol to the liver to be
eliminated. This process is called Reverse Cholesterol transport and is one of the main
mechanisms by which HDL protect against atherosclerotic cardiovascular disease. The
availability of a method to assess RCT is important for the development of new drugs which
affect RCT and may result in useful treatments for atherosclerosis.
This study will evaluate the use of radiolabeled particulate cholesterol administered
intravenously in association with albumin, as a method to study reverse cholesterol
transport (RCT) in humans before and after treatment by niacin by analyzing changes in the
tracer activity in total plasma and lipoproteins. The study population is healthy
volunteers.
We found this trial at
1
site
3400 Spruce St
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
(215) 662-4000
Hospital of the University of Pennsylvania The Hospital of the University of Pennsylvania (HUP) is...
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