Efficacy and Safety of Human Neuregulin-1 to Treat Stable Chronic Heart Failure

This randomized, parallel, placebo-controlled, double-blind, multi-center study will assess
the safety and efficacy of rhNRG-1 also known as Neucardin as a treatment for stable chronic
heart failure.

A total of 120 subjects, who have chronic heart failure with a NYHA classification of II or
III, and are on a stable regimen of ACEI/angiotensin receptor blocker (ARB), beta-blocker,
and/or diuretic for at least 3 months prior to receiving study medication and anticipated to
remain on the stable regimen through the treatment period can enroll as per specific
inclusion and exclusion criteria.

Subjects will be hospitalized for 10 days during the treatment period and will be infused
subcutaneously with rhNRG-1 or placebo.

Inclusion Criteria:

- Age > 18 years.

- Male or female subjects.

- Have chronic heart failure defined as NYHA classification of II or III.

- Be on a stable regimen of ACEI/ARB and/or beta-blocker 3 months prior to receiving
study medication and are expected to remain on a stable HF medication regime
throughout the duration of the trial.

- Left ventricular ejection fraction (LVEF) of < 35% as determined at screening by 2-D
echocardiography.

- Is able to understand and provide informed consent.

- If subject has dilated cardiomyopathy, ischemic heart disease or corrected valvular
heart disease, and had surgery to repair or replace value, the surgery must have been
performed 3 months prior to receiving study medication and the surgical area is
functioning normally.

- Proper birth control must be used at least 3 weeks prior to the study (women only),
during the infusion period of study drug (men and women), 4-weeks after study drug
administration (men and women) and the remaining 11 months in the study follow-up
(women). Women must have a negative pregnancy test at screening.

- No greater than mild pericardial effusion < 0.5 cm on echocardiography (roughly
corresponds to < 100 mL).

- Have an implantable cardioverter-defibrillator (ICD). The ICD should have been
implanted at least 3 months prior to receiving study medication. Patients should
undergo interrogation of their ICDs between 1 and 7 days before randomization to drug
for the previous thirty (30) days. This interrogation would include surveillance for
ventricular arrhythmias as well as assessment of ICD discharge(s) and/or
anti-tachycardia pacing.

Exclusion Criteria:

- Has chronic heart failure classified as NYHA Class I or IV.

- Has a history of any malignancy or positive test as specified in the pre-cancer
screening.

- Have other conditions which in the opinion of the investigator preclude participation
in the study, e.g. serious co-morbidity, known or suspected substance abuse or
non-compliance.

- Has a body weight >350lbs.

- Has had any cause hospitalization 30 days prior to screening.