Dose Escalation/De-escalation Study of Pre-operative Stereotactic Radiosurgery for Brain Metastases(RAD 1002)
| Status: | Completed |
|---|---|
| Conditions: | Cancer, Brain Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 19 - Any |
| Updated: | 5/16/2018 |
| Start Date: | October 2010 |
| End Date: | April 2018 |
RAD 1002: Phase I Dose Escalation/De-escalation Study of Pre-operative Stereotactic Radiosurgery for Brain Metastases
This study will investigate the safety, tolerability, and effectiveness of changing the order
of receiving radiation therapy for treating brain cancer. The investigators hope that
changing the sequence of radiation therapy will lower the risk of cancer spreading throughout
your spinal fluid, which covers your brain and spinal cord.
of receiving radiation therapy for treating brain cancer. The investigators hope that
changing the sequence of radiation therapy will lower the risk of cancer spreading throughout
your spinal fluid, which covers your brain and spinal cord.
This study will attempt to determine the maximum tolerated dose of pre-operative stereotactic
radiosurgery (SRS) in the treatment of brain metastases. Patients will be placed in one of
two dose groups based on index tumor size, and dose will be adjusted according to presence or
absence of dose limiting toxicity (DLT).
Group A: Index Tumor > 2 cm and up to 4 cm in maximum diameter Group B: Index Tumor > 4 cm
and up to 6 cm in maximum diameter
Dose escalation or de-escalation will be conducted via a modified 3+3 method at the following
levels. Group A will start at dose level II. Group B will start at dose level I.
Dose Level I: 12 Gy Dose Level II: 15 Gy
radiosurgery (SRS) in the treatment of brain metastases. Patients will be placed in one of
two dose groups based on index tumor size, and dose will be adjusted according to presence or
absence of dose limiting toxicity (DLT).
Group A: Index Tumor > 2 cm and up to 4 cm in maximum diameter Group B: Index Tumor > 4 cm
and up to 6 cm in maximum diameter
Dose escalation or de-escalation will be conducted via a modified 3+3 method at the following
levels. Group A will start at dose level II. Group B will start at dose level I.
Dose Level I: 12 Gy Dose Level II: 15 Gy
Inclusion Criteria:
- All subjects must have history of histologically confirmed malignancy. Brain biopsy is
not required unless diagnosis is judged to be in doubt by the treating physician.
- Newly diagnosed brain metastases (four or fewer by post-contrast MRI obtained within
six weeks of study entry)
- At least one brain metastasis (index tumor) must be within 2-6 cm in maximum diameter
and deemed appropriate for surgical resection by the treating neurosurgeon.
- Karnofsky performance status (KPS) of greater than or equal to 60
- Age greater than 19
- Life expectancy greater than 12 weeks
- Subjects given written informed consent
Exclusion Criteria:
- Patients with small cell lung cancer and lymphoma are ineligible.
- More than four metastases by baseline post-contrast MRI
- Prior whole brain radiation therapy
- Insufficient recovery from all active toxicities of prior therapies
- Subjects who are deemed to be poor surgical risks by the treating neurosurgeon because
of medical comorbidities
- Pregnant or nursing women
- Women of childbearing potential who are not using an effective method of contraception
are excluded. Women of childbearing potential must have a negative urine or serum
pregnancy test within 24 hours prior to administration of SRS.
We found this trial at
1
site
Birmingham, Alabama 35233
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