Ketones & Mitochondrial Heteroplasmy



Status:Archived
Conditions:Other Indications, Gastrointestinal
Therapuetic Areas:Gastroenterology, Other
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:December 2010
End Date:December 2011

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Trial Summary
Trial Overview
Inclusion Criteria

The current study is a prospective evaluation of the ability of ketosis to shift
mitochondrial DNA (mtDNA) heteroplasmy in subjects harboring a known mutation in their mtDNA
at position 3243 (A>G). Subjects will be given supplemental medium chain triglycerides
(MCTs) for a period of 6 months. mtDNA heteroplasmy will be measured 3 months prior to
treatment, at treatment initiation, and 6 months after initiation.

The primary objective of the current study is to determine if there is a shift in
heteroplasmy in patients harboring the 3243 A>G mtDNA mutation to a more favorable (higher
wild-type) profile while in a state of ketosis.


The current study is a prospective evaluation of the ability of ketosis to shift
mitochondrial DNA (mtDNA) heteroplasmy in subjects harboring a known pathogenic mutation in
their mtDNA at position 3243 (A>G). Subjects will be induced in to ketosis by administration
of supplemental medium chain triglycerides (MCTs) for a period of 6 months. mtDNA
heteroplasmy will be assessed 3 months prior to treatment, at treatment initiation, and 6
months after initiation.

The primary objective of the current study is to determine if there is a shift in
heteroplasmy in patients harboring the 3243 A>G mtDNA mutation to a more favorable (higher
wild-type) genotypic profile while in a state of ketosis.


We found this trial at
1
site
University of Texas Health Science Center at Houston
7000 Fannin St
Houston, Texas 77030
(713) 500-4472
University of Texas Health Science Center at Houston The University of Texas Health Science Center...
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mi
from
Houston, TX
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