F-18 PET Bone Scans Versus Tc-99m Bone Scans for the Diagnosis of Bone Metastases

Compare the diagnostic sensitivity, specificity, and accuracy of 18F-Fluoride PET bone scans
versus traditional 99mTc-MDP bone scans for detecting bone metastases.

Determine if there is a significant change in clinical management between the two types of
scans.

Measure and compare the number of equivocal or uncertain findings that would have caused
additional testing, particularly additional imaging studies, to be performed for confirmation
when using 18F-Fluoride PET bone scans versus 99mTc-MDP bone scans.

To quantify any adverse events resulting from either scan.

To perform subgroup analyses according to cancer cell type.

Inclusion Criteria:

- Patient has cancer

- Has been referred for evaluation of bone metastases

- Patient or patient's legal representative can understand and consent to enrollment in
the study

- Must be 18 years or older

- Can remain still during the scan (approximately one hour)

- Patient has Medicare

Exclusion Criteria:

- Patient does not have Medicare

- Under the age of 18

- Cannot lie still for the necessary time