Nerve Growth Factor in Chronic Pancreatitis
| Status: | Completed |
|---|---|
| Conditions: | Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - 70 |
| Updated: | 4/21/2016 |
| Start Date: | February 2008 |
| End Date: | August 2011 |
This study is to understand the role of nerve growth factor(NGF) and other cytokines in the
pancreatic fluid of patients with chronic pancreatitis.
Hypothesis:
1. Pain does not correlate with changes in the PD morphology suggesting that pain in CP is
not only a mechanical problem
2. Pain in CP correlates better with the levels of NGF in the pancreatic juice. NGF is
variably expressed in different morphological stages of CP and regulates the
sensitivity of the peptidergic nociceptors and is upregulated in pancreatic
inflammation.
pancreatic fluid of patients with chronic pancreatitis.
Hypothesis:
1. Pain does not correlate with changes in the PD morphology suggesting that pain in CP is
not only a mechanical problem
2. Pain in CP correlates better with the levels of NGF in the pancreatic juice. NGF is
variably expressed in different morphological stages of CP and regulates the
sensitivity of the peptidergic nociceptors and is upregulated in pancreatic
inflammation.
Inclusion Criteria:
- Patients with established CP and none of the exclusion criteria mention below.
Exclusion Criteria:
- Failure to obtain consent.
- Any comorbid condition with expected survival < 1 year.
- Patients with pacemaker, implanted metallic prosthesis or other contraindications to
do MRCP.
- Patients < 18 years of age at time of consent
We found this trial at
1
site
Virginia Commonwealth University Medical Center The Virginia Commonwealth University Health System is an urban, comprehensive...
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