Seattle Cardiorenal Remote Ischemic Preconditioning Trial
| Status: | Completed |
|---|---|
| Conditions: | Peripheral Vascular Disease, Renal Impairment / Chronic Kidney Disease, Cardiology, Hospital, Pulmonary |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Nephrology / Urology, Pulmonary / Respiratory Diseases, Other |
| Healthy: | No |
| Age Range: | Any - 18 |
| Updated: | 10/2/2013 |
| Start Date: | December 2010 |
| End Date: | June 2014 |
| Contact: | Christine W Hsu, MD |
| Email: | christine.hsu@seattlechildrens.org |
| Phone: | 206-987-2524 |
Effect of Remote Ischemic Preconditioning in Children Undergoing Cardiac Surgery
Remote Ischemic Preconditioning (RIPC) is a treatment that may be associated with improved
outcomes after cardiac surgery. It can be elicited noninvasively by using a tourniquet to
elicit transient ischemia over a lower extremity. It is thought to promote
anti-inflammatory and cell survival pathways, and thus protect remote organs against future
ischemic injury. We hypothesize that compared to sham treatment, RIPC will be associated
with decreased post-operative acute kidney, myocardial, and lung injury.
In children undergoing cardiac surgery and cardiopulmonary bypass (CPB), our primary aims
are to determine whether RPC is associated with: 1) decreased AKI and 2) decreased acute
myocardial injury. Secondary aims include investigating the effects of RPC on
post-procedure: 1)acute lung injury and 2) morbidity/mortality.
Inclusion Criteria:
Age birth to 18 years Cardiac surgery with planned cardiopulmonary bypass
Exclusion Criteria:
Any contraindication to compression of lower extremity/extremities Body weight <2 kg
Active infection going into surgery On renal replacement therapy (RRT) or mechanical
circulatory support going into surgery On inotropic support going into surgery
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