A Dose Finding Study of TKM-080301 Infusion in Neuroendocrine Tumors (NET) and Adrenocortical Carcinoma (ACC) Patients

Inclusion Criteria:

- Patients must have a histologically and cytologically confirmed solid tumor that is
refractory to standard therapy or for which no standard therapy is known to exist, or
who are not candidates for standard therapy, or non-Hodgkin's lymphoma or Hodgkin's
disease that is refractory to standard therapy (i.e., patients have relapsed following
at least 2 prior therapies) or for which no standard therapy is known to exist. For
the Neuroendocrine (NET) and adrenocortical carcinoma (ACC) expansion cohort subjects
must have histologically or cytologically confirmed, measurable (per RECIST 1.1) NET
or ACC tumor that is refractory to standard therapy or for which no standard therapy
is known to exist, or who are not candidates for standard therapy.

- Patient has an ECOG performance status of 0 - 1,

- Patient has adequate hematologic, hepatic and renal function,

- Patient is seronegative for hepatitis B virus (HBV) and hepatitis C virus (HCV),

- Patients must have a life expectancy of at least 12 weeks.

Exclusion Criteria:

- Unresolved toxicities (> Grade 1) of previous chemotherapy,

- Patients with primary tumors of the central nervous system (CNS),

- Prophylactic hematologic growth factors administered therapy,

- Patient has history of or existing clinically significant cardiovascular disease,

- Patient has a history of clinically significant asthma or COPD requiring daily
medication within the last 6 months,

- Patient has a seizure disorder not controlled on medication,

- Patient has a known or suspected viral, parasitic, or fungal infection,

- Patient has known hypersensitivity or previous severe reactions to oligonucleotide- or
lipid-based products, including liposomal drug products and phospholipid-based
products,

- Patient has been treated with any investigational drugs, biologics, or devices within
28 days prior to study treatment.