A Comparison of Infection Rates Between Two Surgical Sites

The intent of this proposed prospective observational cohort study is to determine if there
is a difference in the incidence of corneal toxicity and/or ototoxicity in study subjects
undergoing Mohs micrographic surgery (MMS) on the face if a povidone-iodine preparation is
used pre-operatively as compared to a chlorhexidine-alcohol preparation. It has recently
been found that the use of a chlorhexidine-alcohol preparation is superior to the use of a
povidone-iodine preparation in preventing post-operative surgical-site infections (SSI) in
patients undergoing clean-contaminated surgery. However, the use of chlorhexidine on the
face has previously been associated with corneal toxicity and ototoxicity. This study will
help to further define previously reported risks of corneal toxicity and ototoxicity
associated with the use of a chlorhexidine solution on the face.

Inclusion Criteria:

- Patients undergoing an outpatient cutaneous surgical procedure on the face.

Exclusion Criteria:

- Those who do not consent to participation

- Those undergoing cutaneous surgery for a lesion on the eyelid margin

- Patients with a history of ongoing eye pain

- History of a pre-existing corneal ulcer within 12 months prior to surgery

- History of a perforated tympanic membrane

- Patients with an active infection at the surgical site at the time of surgery.

- If post-operative follow-up is not completed, the study subject will be excluded from
the analysis.