Relaxation Response Training to Treat Hypertension
| Status: | Completed |
|---|---|
| Conditions: | High Blood Pressure (Hypertension) |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 70 |
| Updated: | 4/21/2016 |
| Start Date: | April 2009 |
| End Date: | June 2011 |
Relaxation Response Training to Treat Hypertension: Effects on Blood Pressure, Biomarkers, and Endothelial Function
Interventions such as Relaxation Response appear to have widespread effects on physiology.
Endothelial function, changes in genomic expression, several biomarkers have been associated
with chronic stress and cardiovascular dysfunction, and there is some suggestion that
elicitation of the Relaxation Response may lead to improvement in-or normalization of-these
factors. By studying the impact of the Relaxation Response on endothelial function, genomic
expression and biomarkers among subjects with hypertension, it may be possible to better
understand the biologic underpinnings of Relaxation Response-type interventions.
Furthermore, with a greater understanding of the physiologic mechanisms by which the
Relaxation Response works, it may be possible to better target other symptoms and conditions
that can be effectively treated by such an intervention.
Endothelial function, changes in genomic expression, several biomarkers have been associated
with chronic stress and cardiovascular dysfunction, and there is some suggestion that
elicitation of the Relaxation Response may lead to improvement in-or normalization of-these
factors. By studying the impact of the Relaxation Response on endothelial function, genomic
expression and biomarkers among subjects with hypertension, it may be possible to better
understand the biologic underpinnings of Relaxation Response-type interventions.
Furthermore, with a greater understanding of the physiologic mechanisms by which the
Relaxation Response works, it may be possible to better target other symptoms and conditions
that can be effectively treated by such an intervention.
General Inclusion Criteria:
- Healthy men and women
- Hypertension (stage 1)
- 18-70 years old
General Exclusion Criteria
- No asthma or nasal allergies
- Non-smokers
- If on anti-hypertensive medication willing to discontinue
- Cannot currently practice Tai Chi, meditation, or yoga regularly
- Current use of the following medications: phosphodiesterase type 5 inhibitors,
long-acting nitrates, systemic corticosteroids, anti-inflammatories,
immunosuppressive or cytotoxic therapies (currently or within the last 12 months),
anabolic steroids, and antidepressants.
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