A Study to Evaluate Safinamide's Effect on Dopamine and Serotonin's Availability by Using Brain Imaging

This is a study of safinamide, an investigational drug for Parkinson disease (PD).
Safinamide is being developed as add-on therapy for the treatment of Parkinson disease. It
is theorized that safinamide acts by increasing the available dopamine in those areas of
the brain where dopamine is decreased as a result of Parkinson;s Disease. . Dopamine in
the brain is involved in controlling body movements. Safinamide has been extensively
studied in animals, and has been shown to increase the level of dopamine in these animals.
Safinamide has also been tested in patients with Parkinson disease. The goal of this
research trial is to see if safinamide is safe and well tolerated and to better understand
how it affects the dopamine system in the brain in individuals with Parkinson disease. Data
from this trial may provide essential information about the effectiveness and safety of
these doses of safinamide in patients with early Parkinson disease, who are already
receiving a stable dose of their normal Parkinson disease treatment.