The Effects of Obesity and Protein Intake on the Kidney
| Status: | Completed |
|---|---|
| Conditions: | Obesity Weight Loss, Renal Impairment / Chronic Kidney Disease |
| Therapuetic Areas: | Endocrinology, Nephrology / Urology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | April 2004 |
| End Date: | April 2014 |
The purpose of this study is to determine if being overweight and eating lots of protein
causes separate changes in the kidney that lead to kidney disease over time. These questions
are important because the number of people who have kidney disease is quickly growing. If
being overweight and eating lots of protein is found to cause kidney disease, then doctors
may be able to limit the number of people with kidney disease by recommending weight loss
and eating less protein
causes separate changes in the kidney that lead to kidney disease over time. These questions
are important because the number of people who have kidney disease is quickly growing. If
being overweight and eating lots of protein is found to cause kidney disease, then doctors
may be able to limit the number of people with kidney disease by recommending weight loss
and eating less protein
The purpose of this study is to test the hypothesis that being obese leads to changes in
kidney function that are independent of, and enhanced by, high dietary protein intake.
Kidney function will be measured by the kidney's ability to filter blood and by the amount
of protein in the urine. The hypothesis will be tested in the following manner: The first
part of the study will involve a crossover design comparing kidney function in obese people
with stable weights on a low and high protein diet ("Low/High Protein Study"). The second
part of the study will compare kidney function in obese people before and after weight
reduction surgery ("Before/After Surgery Study"). Since certain changes in kidney function
may lead to kidney disease over time, it is important to confirm the effects of obesity and
dietary protein intake on the kidney, especially with the current rise in obese people and
the popularity of high protein diets.
kidney function that are independent of, and enhanced by, high dietary protein intake.
Kidney function will be measured by the kidney's ability to filter blood and by the amount
of protein in the urine. The hypothesis will be tested in the following manner: The first
part of the study will involve a crossover design comparing kidney function in obese people
with stable weights on a low and high protein diet ("Low/High Protein Study"). The second
part of the study will compare kidney function in obese people before and after weight
reduction surgery ("Before/After Surgery Study"). Since certain changes in kidney function
may lead to kidney disease over time, it is important to confirm the effects of obesity and
dietary protein intake on the kidney, especially with the current rise in obese people and
the popularity of high protein diets.
Inclusion Criteria:
- Greater than 18 years of age
- Ability to give informed consent
- Not pregnant and using appropriate contraceptive methods, or not of childbearing
potential
- BMI of 30 or higher
Exclusion Criteria:
- Iodine or shellfish allergy
- History of adverse reaction to intravenous contrast
- Dialysis dependence
- Diagnosis of diabetes mellitus or taking medicine for diabetes mellitus
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