Circadian Rhythms and Sleep in Familial DSPS and ASPS
| Status: | Recruiting |
|---|---|
| Conditions: | Insomnia Sleep Studies |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 9/2/2018 |
| Start Date: | September 2003 |
| End Date: | September 2019 |
| Contact: | Sabra Abbott, MD, PhD |
| Email: | sabra.abbott@northwestern.edu |
| Phone: | 312-503-3561 |
Circadian Rhythms and Sleep in Familial Delayed Sleep Phase Syndrome (DSPS) and Advanced Sleep Phase Syndrome (ASPS)
The purpose of this study is to determine the properties of circadian rhythms and sleep
propensity in familial advanced and delayed sleep phase syndrome (DSPS).
propensity in familial advanced and delayed sleep phase syndrome (DSPS).
BACKGROUND:
Tremendous progress in the past few years has led to the identification of several circadian
clock genes. This now makes it possible to determine how alterations of human circadian clock
genes and their expression could lead to differences in circadian and sleep/wake cycle
phenotypes. Of particular interest for understanding genetics of the human circadian system
are individuals with sleep phase disorders, such as DSPS and advanced sleep phase syndrome
(ASPS), because recent studies indicate a genetic basis for these disorders. While it is
assumed that both ASPS and DSPS are disorders of circadian timing, little is known about how
the circadian clock system, or its interaction with sleep processes, are affected in these
individuals.
DESIGN NARRATIVE:
Participants will complete questionnaires and actigraphy to determine sleep patterns and
quality.
Tremendous progress in the past few years has led to the identification of several circadian
clock genes. This now makes it possible to determine how alterations of human circadian clock
genes and their expression could lead to differences in circadian and sleep/wake cycle
phenotypes. Of particular interest for understanding genetics of the human circadian system
are individuals with sleep phase disorders, such as DSPS and advanced sleep phase syndrome
(ASPS), because recent studies indicate a genetic basis for these disorders. While it is
assumed that both ASPS and DSPS are disorders of circadian timing, little is known about how
the circadian clock system, or its interaction with sleep processes, are affected in these
individuals.
DESIGN NARRATIVE:
Participants will complete questionnaires and actigraphy to determine sleep patterns and
quality.
Inclusion Criteria for ASPS Participants:
- Morning type score on the Horne-Ostberg questionnaire
- Advanced melatonin onset
Inclusion Criteria for DSPS Participants:
- Evening type score on the Horne-Ostberg questionnaire
- Delayed melatonin onset
Inclusion Criteria for Controls:
- A stable sleep/wake pattern with a normal phase relationship to the environment and no
history of sleep disorders
Exclusion Criteria for all subjects:
- Sleep disorder, other than DSPS or ASPS, as assessed by the Pittsburgh Sleep Quality
Index and/or by polysomnogram
- History of cognitive or other neurological disorders
- History of Diagnostic and Statistical Manual-IV criteria for any major psychiatric
disorder, alcohol or substance abuse
- Abnormal mood as assessed by the Hamilton Depression Scale
- History of, or concurrent, unstable or serious medical illness
- Current use of psychoactive medications, including antidepressants, anxiolytics,
neuroleptics, anticonvulsants, hypnotics, and stimulant medications
- Shift work
- Having a daily caffeine intake greater than 4 cups per day
- Smoking
- Travel across more than 2 time zones within 90 days of the study
- Pregnancy or the desire to become pregnant during the study period
We found this trial at
1
site
303 East Superior Street
Chicago, Illinois 60611
Chicago, Illinois 60611
Principal Investigator: Phyllis C. Zee, MD, PhD
Phone: 312-503-3561
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