Evaluation and Treatment of Patients With Dermatologic Diseases

Background

This is a training, natural history of disease, and screening protocol for the evaluation,
treatment and follow-up of patients with dermatologic diseases and systemic diseases with
cutaneous manifestations. This protocol was developed to allow subject enrollment for
teaching purposes and to allow for second opinions regarding relatively complicated patients,
and to allow for evaluation of non-invasive tools for the diagnosis and monitoring of
cutaneous manifestations. This protocol promotes a critical link between the NCI, CCR
Dermatology Branch and the local and national extramural medical communities.

Objectives:

- To provide clinical material to fulfill the educational mission of the Dermatology
Branch.

- To learn about the natural history of selected dermatologic diseases.

Eligibility:

All subjects regardless of age, gender, or racial/ethnic group with dermatologic disease or
systemic disease with cutaneous manifestations.

Design:

Patients enrolled in this protocol will be evaluated and treated according to generally
available, standard procedures and therapeutic modalities. Samples of blood and skin will be
studied by routine and specialized investigative methods to establish these patients
diagnosis, response to treatment, and/or disease progression. Non-invasive tools may be used
as part of the examination and assessment of cutaneous manifestations of disease.

- INCLUSION CRITERIA:

Patients of any age, of both genders, and all racial/ethnic groups with dermatologic
diseases or systemic diseases with cutaneous manifestations that will help the Branch
fulfill the objectives.

Women who are pregnant or lactating, will only undergo tests and procedures, and/or receive
medications for which data exists proving minimal risk to the fetus and/or child.

Patients must have a referring physician who will continue to assume primary medical
responsibility of care for the patient during and after enrollment in this protocol.

EXCLUSION CRITERIA:

Any participant who, in the investigator s opinion, would be unable to comply with study
requirements or for whom participation may pose a greater medical risk.