Anti-Tac(90 Y-HAT) to Treat Hodgkin's Disease, Non-Hodgkin's Lymphoma and Lymphoid Leukemia
| Status: | Completed |
|---|---|
| Conditions: | Cancer, Blood Cancer, Lymphoma |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 4/21/2016 |
| Start Date: | April 1997 |
| End Date: | November 2013 |
This study will examine the use of a radioactive monoclonal antibody called yttrium
90-labeled humanized anti-Tac (90 Y-HAT) for treating certain cancers. Monoclonal antibodies
are genetically engineered proteins made in large quantities and directed against a specific
target in the body. The anti-Tac antibody in this study is targeted to tumor cells and is
tagged (labeled) with a radioactive substance called Yttrium-90 (Y-90). The study will
determine the maximum tolerated dose of 90Y-HAT and examine its safety and effectiveness.
Patients 18 years of age and older with Hodgkin's disease, non-Hodgkin's lymphoma and
lymphoid leukemia who have proteins on their cancer cells that react with anti-Tac may be
eligible for this study. Candidates are screened with a medical history and physical
examination, blood and urine tests, electrocardiogram (EKG), chest x-ray, computed
tomography (CT) scan or ultrasound of the abdomen, positron emission tomography (PET) scan
of the neck and body, and skin test for immune reactivity to antigens (similar to skin
tuberculin test).
Before beginning treatment, participants may undergo additional procedures, including the
following:
- Patients with suspicious skin lesions have a skin biopsy. An area of skin is numbed and
a circular piece of skin about 1/4-inch diameter is removed with a cookie cutter-like
instrument.
- Patients with hearing loss have a hearing test.
- Patients with neurological symptoms have a lumbar puncture (spinal tap). A local
anesthetic is given and a needle is inserted in the space between the bones in the
lower back where the cerebrospinal fluid circulates below the spinal cord. A small
amount of fluid is collected through the needle.
- Patients who have not had a bone marrow biopsy within 6 months of screening also
undergo this procedure. The skin and bone at the back of the hip are numbed with a
local anesthetic and a small piece of bone is withdrawn through a needle.
Patients receive 90 Y-HAT in escalating doses to determine the highest dose that can be
safely given. The first group of three patients receives a low dose and, if there are no
significant side effects at that dose, the next three patients receive a higher dose. This
continues with subsequent groups until the maximum study dose is reached. 90 Y-HAT is given
through a vein (intravenous (IV)) over a 2-hour period. In addition, a drug called Pentetate
Calcium Trisodium Inj (Ca-DTPA) is given via IV over 5 hours for 3 days to help reduce the
side effects of the 90Y-HAT. In some patients, the 90 Y-HAT may also be attached to a
radioactive metal called Indium-111 to monitor what happens to the injected material. During
infusion of the drug, patients undergo PET scanning to trace the path of the injected
material in the body. For this procedure, the patient lies in the scanner, remaining in one
position during the entire infusion.
Blood and urine specimens are collected periodically over a 6-week period following the
infusion to determine the level of the radioactive antibody. Bone marrow, lymph node, or
skin biopsies may be done to determine how much of the antibody entered these sites.
Patients whose disease remains stable or improves with therapy may receive up to six more
infusions of 90 Y-HAT, with at least a 6-week interval between treatments.
90-labeled humanized anti-Tac (90 Y-HAT) for treating certain cancers. Monoclonal antibodies
are genetically engineered proteins made in large quantities and directed against a specific
target in the body. The anti-Tac antibody in this study is targeted to tumor cells and is
tagged (labeled) with a radioactive substance called Yttrium-90 (Y-90). The study will
determine the maximum tolerated dose of 90Y-HAT and examine its safety and effectiveness.
Patients 18 years of age and older with Hodgkin's disease, non-Hodgkin's lymphoma and
lymphoid leukemia who have proteins on their cancer cells that react with anti-Tac may be
eligible for this study. Candidates are screened with a medical history and physical
examination, blood and urine tests, electrocardiogram (EKG), chest x-ray, computed
tomography (CT) scan or ultrasound of the abdomen, positron emission tomography (PET) scan
of the neck and body, and skin test for immune reactivity to antigens (similar to skin
tuberculin test).
Before beginning treatment, participants may undergo additional procedures, including the
following:
- Patients with suspicious skin lesions have a skin biopsy. An area of skin is numbed and
a circular piece of skin about 1/4-inch diameter is removed with a cookie cutter-like
instrument.
- Patients with hearing loss have a hearing test.
- Patients with neurological symptoms have a lumbar puncture (spinal tap). A local
anesthetic is given and a needle is inserted in the space between the bones in the
lower back where the cerebrospinal fluid circulates below the spinal cord. A small
amount of fluid is collected through the needle.
- Patients who have not had a bone marrow biopsy within 6 months of screening also
undergo this procedure. The skin and bone at the back of the hip are numbed with a
local anesthetic and a small piece of bone is withdrawn through a needle.
Patients receive 90 Y-HAT in escalating doses to determine the highest dose that can be
safely given. The first group of three patients receives a low dose and, if there are no
significant side effects at that dose, the next three patients receive a higher dose. This
continues with subsequent groups until the maximum study dose is reached. 90 Y-HAT is given
through a vein (intravenous (IV)) over a 2-hour period. In addition, a drug called Pentetate
Calcium Trisodium Inj (Ca-DTPA) is given via IV over 5 hours for 3 days to help reduce the
side effects of the 90Y-HAT. In some patients, the 90 Y-HAT may also be attached to a
radioactive metal called Indium-111 to monitor what happens to the injected material. During
infusion of the drug, patients undergo PET scanning to trace the path of the injected
material in the body. For this procedure, the patient lies in the scanner, remaining in one
position during the entire infusion.
Blood and urine specimens are collected periodically over a 6-week period following the
infusion to determine the level of the radioactive antibody. Bone marrow, lymph node, or
skin biopsies may be done to determine how much of the antibody entered these sites.
Patients whose disease remains stable or improves with therapy may receive up to six more
infusions of 90 Y-HAT, with at least a 6-week interval between treatments.
Background:
Cluster of differentiation 25 (CD25) is expressed on the malignant cells of patients with
certain lymphoid malignancies as well as the non-malignant T cells that surround the
malignant tumor cells of patients with Hodgkin's disease.
Zenapax is a humanized monoclonal antibody that binds to CD25.
Zenapax has been chemically modified by the addition of a chelating molecule to permit
binding of radioactive yttrium.
The yttrium labeled Zenapax binds to CD25 to deliver radiation treatment to the tumor.
Objective:
To assess the toxicity and therapeutic efficacy of (90)Yttrium-labeled humanized
anti-Tac((90)Y-HAT) in patients with Tac-expressing hematologic malignancies.
To determine the sites of localization of radiolabeled Zenapax.
Eligibility:
Patients with Hodgkin's disease and other CD25 positive lymphoid malignancies.
The patient must have a granulocyte of at least 1,200/mm^3 and a platelet count of greater
than 100,000/mm^3.
Design:
Patients will be treated with 10 mCi (if a bone marrow transplant was part of the patient's
previous therapy) or 15 mCi of yttrium labeled Zenapax.
Indium labeled Zenapax is given to demonstrate the antibody distribution and confirm
localization at sites of tumor.
Treatment is given every six weeks if tolerated and patients will be hospitalized for about
one week for each treatment.
Tumor response will be evaluated after every treatment. Stable or responding patients will
continue treatment with evaluations after every cycle of treatment. Patients will be treated
for up to seven cycles.
Cluster of differentiation 25 (CD25) is expressed on the malignant cells of patients with
certain lymphoid malignancies as well as the non-malignant T cells that surround the
malignant tumor cells of patients with Hodgkin's disease.
Zenapax is a humanized monoclonal antibody that binds to CD25.
Zenapax has been chemically modified by the addition of a chelating molecule to permit
binding of radioactive yttrium.
The yttrium labeled Zenapax binds to CD25 to deliver radiation treatment to the tumor.
Objective:
To assess the toxicity and therapeutic efficacy of (90)Yttrium-labeled humanized
anti-Tac((90)Y-HAT) in patients with Tac-expressing hematologic malignancies.
To determine the sites of localization of radiolabeled Zenapax.
Eligibility:
Patients with Hodgkin's disease and other CD25 positive lymphoid malignancies.
The patient must have a granulocyte of at least 1,200/mm^3 and a platelet count of greater
than 100,000/mm^3.
Design:
Patients will be treated with 10 mCi (if a bone marrow transplant was part of the patient's
previous therapy) or 15 mCi of yttrium labeled Zenapax.
Indium labeled Zenapax is given to demonstrate the antibody distribution and confirm
localization at sites of tumor.
Treatment is given every six weeks if tolerated and patients will be hospitalized for about
one week for each treatment.
Tumor response will be evaluated after every treatment. Stable or responding patients will
continue treatment with evaluations after every cycle of treatment. Patients will be treated
for up to seven cycles.
- INCLUSION CRITERIA:
All patients must have a histologically confirmed diagnosis of Hodgkin's disease. Patients
who have had an allogeneic or autologous transplant are eligible if they are more than 100
days post-transplant.
At least 10% of each patient's malignant cells from peripheral blood, lymph node, skin, or
other extranodal sites must react with anti-Tac, as determined by immunofluorescent or
immunoperoxidase staining. Because of the high incidence of Tac positivity in infiltrating
T cells in Hodgkin's disease, patients with cluster of differentiation 25 (CD25) positive
infiltrating T cells will be eligible even if the Hodgkin's cells are negative.
Diagnoses and Stage Disease: 1) Non-Hodgkin's Lymphoma (NHL): Patients with all
histopathologic subtypes of Tac-expressing NHL are eligible. Patients with indolent NHL
Stages II through IV are eligible if they have failed at least one standard therapy and
have disease requiring treatment. Patients with aggressive NHL are eligible if they have
relapse after standard chemotherapy and either are not eligible for or have refused
salvage chemotherapy or bone marrow transplantation.
2) Hodgkin's disease: Patients who are considered to have a low potential for cure with
conventional chemotherapy or radiation therapy are eligible. Specifically, patients with
stages II-IV Hodgkin's disease are eligible if they have relapsed or failed to attain a
complete remission after first-line chemotherapy and either are not eligible for or have
refused salvage chemotherapy or bone marrow transplantation.
3) Cutaneous T-cell Lymphoma (CTCL): Patients with all stages of Tac-expressing CTCL are
eligible with the exception of Stage Ia. Patients with Stages Ib through III are eligible
if they have failed at least one standard therapy. Patients with stage IV are eligible
regardless of whether they have had previous therapy.
4) Peripheral T-cell Lymphoma (PTCL): Patients with stages I - IV PTCL are eligible if
they have relapsed after first-line chemotherapy and either are not eligible for or have
refused salvage chemotherapy or bone marrow transplantation.
Other: Patients with lymphoid leukemias or lymphomas not easily classified in the above
categories will be eligible providing they have failed standard therapy and are not
eligible for or have refused bone marrow transplantation.
Patients must have a Karnofsky performance status of at least 50.
Patients must have a creatinine of less than 2.0 mg/dl. If they patient has an abnormally
elevated creatinine a creatinine clearance must be greater than 50 ml/min.
Patients must have serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic
pyruvic transaminase (SGPT) less than 5 times the upper limit of normal, bilirubin less
than 3.0 unless this is felt to be due to the malignancy.
Patients must not have clinical cardiac failure. Patients with symptomatic pulmonary
dysfunction are eligible only if it is due to the underlying malignancy.
The patient must have a granulocyte count of at least 1,200/mm^3 and a platelet count of
greater than 100,000/mm^3.
Patients must be able to understand and sign informed consent.
Breast-feeding females are not eligible for the study.
Omission of cytotoxic chemotherapy or other systemic therapy of the malignancy for 3 weeks
prior to entry into trial. However, patients receiving corticosteroids will not be
excluded. Patients receiving corticosteroids must be on a stable dose for at least three
weeks before receiving yttrium 90-labeled humanized anti-Tac (90Y-HAT) on this study.
Patients must have a life expectancy of greater than 1 month.
Patients must be at least 18 years old.
EXCLUSION CRITERIA:
Female patients of child bearing potential will be tested for pregnancy; pregnant patients
will be excluded from the study.
Patients who are human immunodeficiency virus (HIV) antibody positive.
Patients with symptomatic disease that is due to malignant involvement of the central
nervous system.
Patients with active second primary cancer.
Patients receiving chronic anticoagulant therapy will be excluded from the study.
Patients requiring urgent chemotherapy or radiation therapy for management of their
malignancy will be excluded.
Patients with evidence of myelodysplastic syndrome or chromosomal abnormalities in their
screening bone marrow evaluation
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
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