Follow Up of Patients Treated With Radiotherapy

Background:

- This protocol acknowledges that it is in the interest of the NIH and ROB, as well as our
patients, to continue to follow those who have been treated with radiotherapy at ROB and
are not otherwise eligible for current active research protocols.

- It also provides a mechanism for the correlation and interpretation of disparate data
for research into the long term side effects and outcomes for a variety of disease
entities and treatments, such as combined modality treatment, MoAb, PDT, radiation
modifiers, intraoperative radiotherapy, etc.

Objectives:

-The objective of this protocol is to provide follow-up care for patients previously treated
with radiotherapy in the Radiation Oncology Branch (ROB) in order to assess the late effects
of treatment and the natural history of disease.

Eligibility:

-Patients who received radiation therapy at the NCI IRB who are long-term survivors and are
not currently entered on an active research protocol.

Design:

- This is a natural history protocol that will provide follow-up care for Radiation
Oncology Branch patients and will allow for appropriate long-term follow up care and
evaluation, including NIH consultation services as required.

- It will be made clear to patients in the consent form, that data collected in their
follow-up may be used anonymously for publications concerning the natural history of
disease processes and long-term effects of treatment.

- INCLUSION CRITERIA:

Radiation Oncology Branch investigator deems that it is in the best interests of the
patient and the NCI/ROB for the patient to be seen in follow-up in the ROB clinic.

Patient is able to provide informed consent.

Patient must have a primary physician in the community to whom records and appropriate
follow-up management can be given. Social services will be enlisted for any patients who
lack health insurance, etc.

Patients who have received radiotherapy in the ROB and may or may not be officially entered
on a clinical protocol. Some patients treated prior to 1993 may not have been officially
entered on a clinical protocol.

Age greater than or equal to 18 years of age

EXCLUSION CRITERIA:

Patients who are on another active primary research protocol at NIH.