Chronic Kidney Disease in Children Prospective Cohort Study (CKiD)

Since its inception in 2003, the scientific aims of CKiD have been to determine the risk
factors for decline in kidney function and to define how progressive decline in kidney
function impacts biomarkers of risk factors for cardiovascular disease; neurocognitive
function and behavior; and growth failure and its associated morbidity.

Inclusion Criteria:

- Age between 1 and 16 years (before 17th birthday) for Cohorts 1 and 2; age between 6
months and 16 years (before 17th birthday) for Cohort 3

- Estimated (based on SCr) Schwartz GFR between 30 and 90 ml/min|1.73m2 for Cohort 1 OR
an estimated GFR between 45 and 90 ml/min|1.73m2 based on the updated Schwartz formula
for Cohort 2

- Willingness and ability to provide informed consent and assent

- For Cohort 3, children with non-glomerular diagnosis and duration of kidney disease
less than 5 years will be enrolled.

Exclusion Criteria:

- Renal, other solid organ, bone marrow or stem cell transplantation

- Dialysis treatment within the past three months

- Cancer diagnosis or HIV diagnosis/treatment within last twelve months

- Current pregnancy or pregnancy within past twelve months

- Inability to complete major data collection procedures

- Current enrollment in a randomized clinical trial in which the specific treatment is
unknown

- Not fluent in English or Spanish

- Plans to move out of area of any participating CKiD site (Families can be transferred
to another CKiD site if they move)

- History of structural heart disease

- Genetic syndromes involving the central nervous system (e.g., Downs syndrome)

- History of severe to profound mental retardation (i.e., intelligence quotient (IQ)<40,
significant impairment in adaptive function and/or inability to independently execute
self-care skills)

- For cohort 3, children who are expected to receive renal replacement therapy within 6
months of date of enrollment will not be recruited