NM404 as an Imaging Agent in Patients With NSCLC
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Lung Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/14/2018 |
| Start Date: | January 2004 |
| End Date: | May 2018 |
NM404 as an Imaging Agent in Patients With Non-small Cell Lung Cancer (NSCLC)
This study seeks to determine imaging characteristics of radiolabelled 131-I-NM404 in ten
patients with cancer, including calculations of PKs, radiation dosimetry, biodistribution,
and optimal imaging times (part 1 - complete).
In addition, specific tumor accumulation and metabolic fate of 131-I-NM404 will be determined
in NSCLC tumors collected in 5 patients (part 2 - complete). Lastly, the study will collect
preliminary data on imaging NSCLC tumors in up to 12 patients with evaluable disease (part 3
- ongoing).
patients with cancer, including calculations of PKs, radiation dosimetry, biodistribution,
and optimal imaging times (part 1 - complete).
In addition, specific tumor accumulation and metabolic fate of 131-I-NM404 will be determined
in NSCLC tumors collected in 5 patients (part 2 - complete). Lastly, the study will collect
preliminary data on imaging NSCLC tumors in up to 12 patients with evaluable disease (part 3
- ongoing).
Inclusion Criteria: Part 3
- Histologically or cytologically documented NSCLC with measurable of disease
- Disease is evaluable by CT scan
- At least 18 years old. Women cannot be pregnant or breastfeeding
- Karnofsky score >/= to 60
- Adequate renal/hepatic function
- Adequate blood cell count levels
Exclusion Criteria:
- Concomitant infection
- Other active cancers
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