Mechanisms of Endothelial Cell Dysfunction in Sleep Apnea
| Status: | Completed |
|---|---|
| Conditions: | Insomnia Sleep Studies, Pulmonary |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 21 - Any |
| Updated: | 2/6/2019 |
| Start Date: | April 2009 |
| End Date: | August 2015 |
Sleep apnea is a common sleep disorder characterized by temporary stops in breathing during
sleep and has been associated with the development of cardiovascular disease. This research
will investigate one potential mechanism leading to the development of cardiovascular
disorder, specifically, the blockage of blood vessels called "vascular occlusion", in
subjects with sleep apnea. A group of healthy controls will be used for comparison. All
subjects will undergo clinical evaluation followed by an overnight sleep study and a morning
blood draw. Subjects with sleep apnea will be treated according to standard clinical
management and followed under the research protocol for one month. At the end of one month, a
repeat blood draw will be performed on the sleep apnea subjects for comparative analysis. If
a control subject is found to have any abnormality during this research study, he or she will
be referred for further clinical evaluation.
sleep and has been associated with the development of cardiovascular disease. This research
will investigate one potential mechanism leading to the development of cardiovascular
disorder, specifically, the blockage of blood vessels called "vascular occlusion", in
subjects with sleep apnea. A group of healthy controls will be used for comparison. All
subjects will undergo clinical evaluation followed by an overnight sleep study and a morning
blood draw. Subjects with sleep apnea will be treated according to standard clinical
management and followed under the research protocol for one month. At the end of one month, a
repeat blood draw will be performed on the sleep apnea subjects for comparative analysis. If
a control subject is found to have any abnormality during this research study, he or she will
be referred for further clinical evaluation.
The importance of this project is to investigate mechanisms of vascular disease in sleep
apnea and determine pathways for intervention, aiming to prevent the development of
cardiovascular disease in these individuals.
This proposed research aims to evaluate both NTPDase activity in lymphocytes and levels of
circulating endothelial cells (CECs) in patients with intermittent hypoxemia (IH) due to
obstructive sleep apnea (OSA) and healthy controls. This is an original approach to define
mechanisms which underlie the high incidence of occlusive vascular events in patients with
OSA. The evaluation of such pathophysiological mechanisms will lead to a better understanding
of the pathways involved and the development of therapeutic strategies targeting the
reduction or avoidance of endothelial injury with the ultimate goal of reducing morbidity and
mortality associated with these pathologic events in sleep apnea. The standard of care will
be used in this protocol, which involves the use of CPAP (continuous positive airway
pressure) for treating sleep apnea.
apnea and determine pathways for intervention, aiming to prevent the development of
cardiovascular disease in these individuals.
This proposed research aims to evaluate both NTPDase activity in lymphocytes and levels of
circulating endothelial cells (CECs) in patients with intermittent hypoxemia (IH) due to
obstructive sleep apnea (OSA) and healthy controls. This is an original approach to define
mechanisms which underlie the high incidence of occlusive vascular events in patients with
OSA. The evaluation of such pathophysiological mechanisms will lead to a better understanding
of the pathways involved and the development of therapeutic strategies targeting the
reduction or avoidance of endothelial injury with the ultimate goal of reducing morbidity and
mortality associated with these pathologic events in sleep apnea. The standard of care will
be used in this protocol, which involves the use of CPAP (continuous positive airway
pressure) for treating sleep apnea.
Study Group 1: Sleep Apnea
Inclusion Criteria:
- 21 years or older
- Presence of intermittent hypoxemia (IH) and obstructive sleep apnea (OSA)
- No diagnosis of hypertension, coronary artery disease, diabetes, stroke, or evidence
of underlying vascular disease
Exclusion Criteria:
- Smoking
- Pregnancy
- Known cardiovascular disease, stroke, or diabetes
- Current or previous treatment for sleep apnea
- Central or Cheyne-Stokes sleep apnea
- Use of supplemental oxygen at night
- Alcohol abuse
- Regular use of sedatives
- Regular use of aspirin or cholesterol lowering agents
Study Group 2: Normal Controls
Inclusion Criteria:
- 21 years or older
- No diagnosis of intermittent hypoxemia (IH) or obstructive sleep apnea (OSA)
- No diagnosis of hypertension, coronary artery disease, diabetes, stroke, or evidence
of underlying vascular disease
Exclusion Criteria:
- Smoking
- Pregnancy
- Known cardiovascular disease, stroke, or diabetes
- Use of supplemental oxygen at night
- Alcohol abuse
- Regular use of sedatives
- Regular use of aspirin or cholesterol lowering agents
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