Previously Untreated Advanced Non-Small Cell Lung Cancer (NSCLC)
| Status: | Recruiting |
|---|---|
| Conditions: | Lung Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/2/2016 |
| Contact: | Elta Field |
| Email: | field-elta@cooperhealth.edu |
| Phone: | 856-325-6759 |
Phase II Trial of Bevacizumab (Avastin) Plus Pemetrexed (Alimta) and Carboplatin in Previously Untreated Advanced Non-Small Cell Lung Cancer (NSCLC)
Avastin is a novel antiangiogenic agent that has recently been shown to improve response
rates and survival of patients with advanced nonsquamous non-small cell lung cancer when
added to front-line carboplatin/paclitaxel chemotherapy, and is now being routinely
incorporated into the treatment of these patients. Alimta is a recently approved
chemotherapeutic that has shown activity against non-small cell lung cancer when given alone
and in combination with carboplatin, has a favorable toxicity profile andrequires only a
brief (10 minute) infusion time. Therefore we propose to study the combination of Avasin,
Alimta, and Carboplatin administered as front-line therapy to patients with advanced
nonsquamous non-small cell lung cancer.
rates and survival of patients with advanced nonsquamous non-small cell lung cancer when
added to front-line carboplatin/paclitaxel chemotherapy, and is now being routinely
incorporated into the treatment of these patients. Alimta is a recently approved
chemotherapeutic that has shown activity against non-small cell lung cancer when given alone
and in combination with carboplatin, has a favorable toxicity profile andrequires only a
brief (10 minute) infusion time. Therefore we propose to study the combination of Avasin,
Alimta, and Carboplatin administered as front-line therapy to patients with advanced
nonsquamous non-small cell lung cancer.
Inclusion Criteria:
I am 18 years of age or older. I have advanced non-small lung cancer. I have not had any
major surgical procedures within 28 days prior to my starting treatment.
I have high blood pressure that is controlled. I am not on heparin, coumadin or lovonox
for treatment of medical conditions. I do not have serious wound healing problems. I have
not received any previous treatment, except radiation therapy for my disease.
Exclusion Criteria:
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