Sildenafil for Treatment of Priapism in Men With Sickle Cell Anemia
| Status: | Completed |
|---|---|
| Conditions: | Anemia |
| Therapuetic Areas: | Hematology |
| Healthy: | No |
| Age Range: | 14 - 45 |
| Updated: | 10/2/2013 |
| Start Date: | June 2008 |
| End Date: | December 2013 |
| Contact: | Irene N. Trueheart, RN |
| Email: | itruehe1@jhmi.edu |
| Phone: | (443) 287-1011 |
This research is being done to see if the drug sildenafil (Viagra) has an effect on the
frequency of recurrent priapism and the quality of life in males with sickle cell disease.
Inclusion Criteria:
- Ages 14 to 45, inclusive
- Episodes of prolonged penile erection in the absence of sexual interest or desire,
with an average frequency of at least twice weekly, when averaged over the previous
four weeks
- Able to provide informed consent or assent
Exclusion Criteria:
- Use of chronic nitrates or recreational use of nitrate containing products
- Use of a PDE5 inhibitor within the previous two weeks
- Alcohol use exceeding two standard drinks daily
- Hypersensitivity to sildenafil
- Estimated glomerular filtration rate <50ml/min
- Known cirrhosis
- Retinitis pigmentosa
- Necessary use of a P450 3A4 inhibitor
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