A Long-Term Safety And Tolerability Extension Study Of Bapineuzumab In Alzheimer Disease Patients



Status:Terminated
Conditions:Alzheimer Disease
Therapuetic Areas:Neurology
Healthy:No
Age Range:51 - 90
Updated:4/21/2016
Start Date:December 2009
End Date:November 2012

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A Phase 3 Extension, Multicenter, Long Term Safety And Tolerability Trial Of Bapineuzumab (Aab 001, Eln115727) In Subjects With Alzheimer Disease Who Are Apolipoprotein E 4 Carriers And Participated In Study 3133k1-3001-us Or Study 3133k1-3001-ww.

The purpose of this study is to assess the long-term safety and tolerability of bapineuzumab
in subjects with Alzheimer Disease who participated in study 3133K1-3001(NCT00676143). Over
250 sites will participate in over 26 countries. Subjects will receive bapineuzumab. Each
subject's participation will last approximately 4 years.


Inclusion Criteria:

- Subject has completed study 3133K1-3001 (Week 78) and brain magnetic resonance
imaging (MRI) scan consistent with the diagnosis of Alzheimer Disease

- Mini-Mental Status Examination (MMSE) >=10 at screening

- Caregiver able to attend all clinic visits with subject

Exclusion Criteria:

- Any medical or psychiatric contraindication or clinically significant abnormality
that, in the investigator's judgment, will substantially increase the risk associated
with the subject's participation in and completion of the study or could preclude the
evaluation of the subject's response.

- Any significant brain MRI abnormality.

- Use of any investigational drugs or devices, other than bapineuzumab within the last
60 days prior to screening
We found this trial at
64
sites
Birmingham, Alabama 35294
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1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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1000 Alpine
Boulder, Colorado 80304
303-443-7229
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100 West Gore St # 202
Orlando, Florida 32806
(407) 426-9299
Compass Research LLC Compass Research is a clinical research company dedicated to testing new medications...
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Orlando, FL
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5430 Fredericksburg Road
San Antonio, Texas 78229
210-377-2873
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3603 Paesanos Parkway
San Antonio, Texas 78231
210-614-4884
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Abington, Pennsylvania 19001
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Abington, Pennsylvania 19001
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Abington, Pennsylvania 19001
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Atlantis, Florida 33462
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Atlantis, FL
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Atlantis, Florida 33462
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Boulder, Colorado 80304
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Buenos Aires,
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Charleston, SC
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171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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Columbus, Ohio 43210
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Dallas, Texas 75214
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Delray Beach, Florida 33445
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Denver, Colorado 80218
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East Lansing, Michigan 48824
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East Providence, Rhode Island 02914
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Eatontown, New Jersey 07724
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Elk Grove Village, IL
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Fairfield, CT
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Goodyear, Arizona 85395
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Greenwich, Connecticut 06830
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Greenwich, Connecticut 06830
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Hattiesburg, Mississippi 39401
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Jenkintown, Pennsylvania 19046
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Kansas City, Missouri 64114
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Lake Charles, Louisiana 70601
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Lawrenceville, Georgia 30046
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Lawrenceville, Georgia 30046
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Little Rock, Arkansas 72205
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MDR
LiverPool, New York 13088
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Liverpool, New York 13088
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Manchester, NJ
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North Charleston, South Carolina 29406
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Norwalk, Connecticut 06851
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Palm Beach Gardens, FL
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111 S 11th St
Philadelphia, Pennsylvania 19107
(215) 955-6000
Thomas Jefferson University Hospital Our hospitals in Center City Philadelphia share a 13-acre campus with...
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1020 Walnut St
Philadelphia, Pennsylvania 19107
(215) 955-6000
Thomas Jefferson University We are dedicated to the health sciences and committed to educating professionals,...
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Phoenix, Arizona 85006
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Phoenix, Arizona 85032
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Phoenix, Arizona 85050
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Pittsfield, Massachusetts 01201
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Port Charlotte, Florida 33952
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Port Charlotte, Florida 33952
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Portland, Oregon 97210
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Portland, Oregon 97225
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Raleigh, North Carolina 27607
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Raleigh, North Carolina 27607
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Raleigh, North Carolina 27607
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Raleigh, North Carolina 27607
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San Antonio, Texas 78231
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San Antonio, Texas 78258
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San Francisco, California
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Sarasota, Florida 34243
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Springfield, Massachusetts 01104
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Toms River, New Jersey 08755
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