B Cell Repertoires in Chronic Lymphocytic Leukemia and Aging
| Status: | Recruiting |
|---|---|
| Conditions: | Blood Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/6/2019 |
| Start Date: | July 1998 |
| End Date: | January 2021 |
| Contact: | Yasmine Kieso, MSCR |
| Email: | ykieso@nshs.edu |
B-CLL is the most prevalent leukemia in the Western hemisphere, accounting for ~25% of all
leukemia's (1). This disease occurs virtually exclusively in the aging population, with the
median age of diagnosis ranging between the mid 60s and the early 70s. Indeed, its occurrence
before the age of 50 is quite unusual. This increase in occurrence with age is not unique to
B-CLL; rather, it is characteristic several B cell lymphoproliferative disorders (e.g.,
non-Hodgkin's lymphoma, multiple myeloma). Gender and race also influence the development of
B-CLL. Thus, the ratio of men: women is ~2:1 and the prevalence is increased in Caucasians.
The rate of occurrence of B-CLL among Asians is significantly lower than for Caucasians and
this does not increase with immigration to the West. DNA sequence analyses performed in our
laboratory and in those of others indicate that B-CLL cells from unrelated patients share Ig
V gene characteristics. These include the use of selected genes, the association of these
genes with certain D and JH gene segments that code for unique CDR3 motifs, and the
occasional occurrence of highly similar VHDJH + VLJL pairs. In ~50% cases, these rearranged
genes are mutated, whereas in the others mutations are infrequent; this difference is related
to the VH gene family used by the B-CLL cell.
leukemia's (1). This disease occurs virtually exclusively in the aging population, with the
median age of diagnosis ranging between the mid 60s and the early 70s. Indeed, its occurrence
before the age of 50 is quite unusual. This increase in occurrence with age is not unique to
B-CLL; rather, it is characteristic several B cell lymphoproliferative disorders (e.g.,
non-Hodgkin's lymphoma, multiple myeloma). Gender and race also influence the development of
B-CLL. Thus, the ratio of men: women is ~2:1 and the prevalence is increased in Caucasians.
The rate of occurrence of B-CLL among Asians is significantly lower than for Caucasians and
this does not increase with immigration to the West. DNA sequence analyses performed in our
laboratory and in those of others indicate that B-CLL cells from unrelated patients share Ig
V gene characteristics. These include the use of selected genes, the association of these
genes with certain D and JH gene segments that code for unique CDR3 motifs, and the
occasional occurrence of highly similar VHDJH + VLJL pairs. In ~50% cases, these rearranged
genes are mutated, whereas in the others mutations are infrequent; this difference is related
to the VH gene family used by the B-CLL cell.
Inclusion Criteria:
- 18 years of age Patients must be willing to be contacted in the future
Exclusion Criteria:
- Patients who are known to be anemic, with a hemoglobin <8 PAtients who are known to be
infected with HIV
We found this trial at
1
site
Manhasset, New York 11030
Principal Investigator: Nicholas Chiorazzi, M.D.
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