Collection of Tissue Samples From Patients With Stage III or Stage IV Ovarian Epithelial Cancer
| Status: | Completed |
|---|---|
| Conditions: | Ovarian Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 4/21/2016 |
| Start Date: | November 2009 |
| End Date: | October 2015 |
Orthotopic Propagation of Primary Human Ovarian Tumors for Preclinical Investigation of Novel Anti-Tumor Agents.
RATIONALE: Collecting and storing samples of tumor tissue and ascites fluid from patients to
test in the laboratory may help the study of cancer.
PURPOSE: This pre-clinical research study is collecting tissue samples and ascites fluid
from patients with stage III or stage IV ovarian/primary peritoneal/fallopian tube
epithelial cancer.
test in the laboratory may help the study of cancer.
PURPOSE: This pre-clinical research study is collecting tissue samples and ascites fluid
from patients with stage III or stage IV ovarian/primary peritoneal/fallopian tube
epithelial cancer.
OBJECTIVES:
- To generate a translational ovarian cancer model using tumor tissue and cells from
patients with stage III-IV ovarian/primary peritoneal/fallopian tube epithelial cancer
for drug response and development.
OUTLINE: Tissue and fluid samples are collected at the time of surgery or paracentesis and
used in laboratory experiments and in animal models. Health data is collected from patient
medical records before, during, and after surgery.
After surgery, patients are followed up for 5 years.
- To generate a translational ovarian cancer model using tumor tissue and cells from
patients with stage III-IV ovarian/primary peritoneal/fallopian tube epithelial cancer
for drug response and development.
OUTLINE: Tissue and fluid samples are collected at the time of surgery or paracentesis and
used in laboratory experiments and in animal models. Health data is collected from patient
medical records before, during, and after surgery.
After surgery, patients are followed up for 5 years.
INCLUSION:
• Females age 18-80 with a diagnosis of Stage III-IV ovarian cancer, primary fallopian
tube, or primary peritoneal papillary serous carcinoma and scheduled treatment for
epithelial ovarian malignancies.
EXCLUSION:
- Patients with less than Stage III epithelial ovarian cancer, primary fallopian tube,
or primary peritoneal papillary serous carcinoma
- Patients who have received prior chemotherapy
- Patients who have nonepithelial ovarian cancer, primary fallopian tube, or primary
peritoneal carcinoma
- Patients who have malignancy other than ovarian cancer, primary fallopian tube, or
primary peritoneal carcinoma
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Vanderbilt-Ingram Cancer Center The Vanderbilt-Ingram Cancer Center, located in Nashville, Tenn., brings together the clinical...
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