A Research Study Looking at Specific Tissue of the Umbilical Cord
| Status: | Recruiting |
|---|---|
| Conditions: | Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | June 2010 |
| End Date: | June 2016 |
| Contact: | Omar Aljitawi, MD |
| Email: | oaljitawi@kumc.edu |
| Phone: | 913-588-6030 |
Decellularization of Umbilical Cord Wharton's Jelly for Tissue Regenerative Applications Including Avascular Necrosis
The purpose of this study is to isolate Umbilical cord Wharton's jelly matrix to be used as
a scaffold for tissue regenerative applications, including avascular necrosis.
a scaffold for tissue regenerative applications, including avascular necrosis.
Our working hypothesis is that umbilical cord blood Wharton's Jelly matrix has all the
biochemical and biomechanical characteristics needed in an ideal scaffold for tissue
engineering. Accordingly, we expect matrix to support the growth and differentiation of
transplanted mesenchymal stem cells. The first step in this effort is to isolate Wharton's
Jelly matrix by decellularization. The second step will be to test the ability of this
matrix to support the growth and differentiation of transplanted mesenchymal stem cells. The
third step will be to pursue preliminary animal testing to study the ability of this matrix
to support bone tissue regeneration in vivo.
biochemical and biomechanical characteristics needed in an ideal scaffold for tissue
engineering. Accordingly, we expect matrix to support the growth and differentiation of
transplanted mesenchymal stem cells. The first step in this effort is to isolate Wharton's
Jelly matrix by decellularization. The second step will be to test the ability of this
matrix to support the growth and differentiation of transplanted mesenchymal stem cells. The
third step will be to pursue preliminary animal testing to study the ability of this matrix
to support bone tissue regeneration in vivo.
Inclusion Criteria:
- Pregnant Women
- 18 years of age or older
- willing to donate umbilical cord units
Exclusion Criteria:
- less than 18 years of age
- Has Hepatitis or HIV
- Considered High Risk
- Scheduled for C-Section due to complications during current pregnancy
- Delivered prior to Full Term
We found this trial at
2
sites
2401 Gillham Rd
Kansas City, Missouri 64108
Kansas City, Missouri 64108
(816) 234-3000
Phone: 816-234-3519
Children's Mercy Hospital Children's Mercy Hospitals and Clinics continues redefining pediatric medicine throughout the Midwest...
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3901 Rainbow Blvd
Kansas City, Kansas 66160
Kansas City, Kansas 66160
(913) 588-5000
Principal Investigator: Omar Aljitawi, MD
Phone: 913-588-6030
University of Kansas Medical Center The University of Kansas Medical Center serves Kansas through excellence...
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