Axitinib For The Treatment Of Advanced Hepatocellular Carcinoma



Status:Completed
Conditions:Liver Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:1/11/2019
Start Date:December 6, 2010
End Date:December 20, 2016

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Trial Summary
Trial Overview
Inclusion Criteria

A MULTICENTER, GLOBAL, RANDOMIZED, DOUBLE-BLIND STUDY OF AXITINIB PLUS BEST SUPPORTIVE CARE VERSUS PLACEBO PLUS BEST SUPPORTIVE CARE IN PATIENTS WITH ADVANCED HEPATOCELLULAR CARCINOMA FOLLOWING FAILURE OF ONE PRIOR ANTIANGIOGENIC THERAPY

The study is designed to demonstrate that axitinib plus best supportive care is superior to
placebo plus best supportive care in prolonging survival in patients with advanced
hepatocellular carcinoma.


Inclusion Criteria:

- Locally advanced or metastatic HCC

- Failure of one prior antiangiogenic therapy including sorafenib, bevacizumab and
brivanib.

- Child-Pugh Class A or B (score 7 only) disease.

Exclusion Criteria:

- Prior treatment of advanced HCC with more than one prior first-line systemic therapy.

- Any prior local therapy within 2 weeks of starting the study treatment.

- Presence of hepatic encephalopathy and/or clinically relevant ascites.

- Presence of main portal vein invasion by HCC.
We found this trial at
13
sites
Universitair Ziekenhuis Gent
Gent, 9000
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Gent,
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Hospital of the University of Pennsylvania
3400 Spruce St
Philadelphia, Pennsylvania 19104
 (215) 662-4000
Hospital of the University of Pennsylvania The Hospital of the University of Pennsylvania (HUP) is...
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Philadelphia, PA
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University of Michigan
500 S State St
Ann Arbor, Michigan 48109
(734) 764-1817
University of Michigan The University of Michigan was founded in 1817 as one of the...
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Ann Arbor, MI
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Alta Bates Summit Comprehensive Cancer Center
2450 Ashby Ave.
Berkeley, California 94705
(510) 204-4444
Alta Bates Summit Comprehensive Cancer Center Our Comprehensive Cancer Services are comprised of exceptional, state-of-the-art...
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Berkeley, CA
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UCSD Medical Center- La Jolla
La Jolla, California 92037
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La Jolla, CA
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Moores UCSD Cancer Center
La Jolla, California 92093
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La Jolla, CA
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Comprehensive Cancer Centers of Nevada
9280 W. Sunset Road Suite 100
Las Vegas, Nevada 89148
702.952.1251
Comprehensive Cancer Centers of Nevada Comprehensive Cancer Centers of Nevada (CCCN) is the award-winning multidisciplinary...
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Las Vegas, NV
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Nebraska Methodist Hospital
8303 Dodge Street
Omaha, Nebraska 68114
(402) 354–4000
Nebraska Methodist Hospital Methodist Hospital is a general medical and surgical hospital in Omaha, NE....
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Omaha, NE
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University of California, Irvine Medical Center
101 The City Drive South
Orange, California 92868
714-456-7890
University of California, Irvine Medical Center We are UC Irvine Health. We are a devoted...
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from
Orange, CA
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Florida Hospital Transplant Center, Liver Unit
Orlando, Florida 32804
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Orlando, FL
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Penn Presbyterian Medical Center
Philadelphia, Pennsylvania
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Philadelphia, PA
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UCSD Medical Center - Hillcrest
San Diego, California 92103
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San Diego, CA
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Moffitt Cancer Center and Research Institute
Tampa, Florida 33617
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Tampa, FL
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