Inflammation and the Host Response to Injury (Burns)
| Status: | Completed |
|---|---|
| Conditions: | Other Indications, Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 3/9/2019 |
| Start Date: | April 2004 |
| End Date: | September 2018 |
Inflammation and the Host Response to Injury
The purpose of this study is to help improve our understanding of the biology involved in the
body's response to serious trauma or burn injury. The host response to trauma and burns is a
collection of physiological and pathophysiological processes that depend critically upon the
regulation of the human innate immune system, with particular emphasis on the inflammatory
component of that system. No single research center or small group of centers has the
capacity to delineate the integrated response of this complex biological system, which
involves multiple molecular and genetic interactions that vary in time. Our proposal promotes
the identification of important dynamic relationships that regulate the integration of this
complex biological system, with the expectation that this understanding will ultimately
impact the diagnosis, prognosis, and treatment of the hospitalized, severely injured patient.
body's response to serious trauma or burn injury. The host response to trauma and burns is a
collection of physiological and pathophysiological processes that depend critically upon the
regulation of the human innate immune system, with particular emphasis on the inflammatory
component of that system. No single research center or small group of centers has the
capacity to delineate the integrated response of this complex biological system, which
involves multiple molecular and genetic interactions that vary in time. Our proposal promotes
the identification of important dynamic relationships that regulate the integration of this
complex biological system, with the expectation that this understanding will ultimately
impact the diagnosis, prognosis, and treatment of the hospitalized, severely injured patient.
This large-scale collaborative project provides the means to acquire the necessary new
knowledge directly in humans. Knowledge will be acquired using diverse state-of-the-art
genomic and proteomic technologies, a highly complex clinical, proteomic, and genomic
database, as well as newly-developed, novel analytical tools to probe this complex dataset.
Our analytical capabilities at the genomic and proteomic level are now rapidly evolving and
our ability to link these genomic and proteomic data to pathways and functional modules will
help us more closely link this cellular data to immunological processes and ultimately, to
the phenotypic response (i.e., trajectory) in the injured host. As a result, potential
interventions, whether through our Program or other funding mechanisms, can be more
effectively designed.
knowledge directly in humans. Knowledge will be acquired using diverse state-of-the-art
genomic and proteomic technologies, a highly complex clinical, proteomic, and genomic
database, as well as newly-developed, novel analytical tools to probe this complex dataset.
Our analytical capabilities at the genomic and proteomic level are now rapidly evolving and
our ability to link these genomic and proteomic data to pathways and functional modules will
help us more closely link this cellular data to immunological processes and ultimately, to
the phenotypic response (i.e., trajectory) in the injured host. As a result, potential
interventions, whether through our Program or other funding mechanisms, can be more
effectively designed.
Inclusion Criteria:
- Burn patients of all ages with 20% or greater of total body surface area burns that
require surgical treatment
- Burn patients admitted to the burn unit within 96 hours (4 days) of burn injury
All patients meeting these criteria are entered into the epidemiologic database and
assessed for specific exclusion criteria to establish whether serial blood draws are
warranted.
Exclusion Criteria:
- Injury caused by chemical agent
- Deep injury caused by conduction of electrical current or charge
- Decision not to treat due to severity of injury
- Anoxic brain injury that is not expected to result in complete recovery
- Associated multiple injuries exclusive of burns (ISS >=25)
- Pre-morbid condition: Severe congestive heart failure (measured ejection fraction
<20%)
- Pre-morbid condition: Malignancy currently under treatment
- Pre-morbid condition: Medical condition requiring systemic glucocorticoid treatment
- Pre-morbid condition: current systemic immunosuppression for organ transplant or
chronic inflammatory condition
We found this trial at
4
sites
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