Multiple Ascending Doses of AMG 139 in Healthy and Crohn's Disease Subjects

Inclusion Criteria:

Part A - Healthy Subjects:

- Healthy male or female of non-reproductive potential subjects between 18 to 45
years-of-age

- Body mass index (BMI) between 18 and 32 kg/m2

- Normal or clinically acceptable physical examination, clinical laboratory values, and
ECG

- Additional inclusion criteria apply

Part B - Crohn's Subjects:

- Male or female subjects with CD between 18 to 55 years-of-age

- Body mass index (BMI) between 18 and 32 kg/m2

- Normal or clinically acceptable physical examination (PE), clinical laboratory
values, and ECG; clinically acceptable PE includes evidence of mild to severe CD

- Diagnosis of ileal or ileo-colonic CD for a minimum of 6 months

- Mild to severe CD defined by a Crohn's Disease Activity Index (CDAI) score equal to
or greater than 180 and equal to or less than 450

- Elevated fecal calprotectin and CRP

- Additional inclusion criteria apply

Exclusion Criteria:

Parts A - Healthy Subjects:

- History or evidence of a clinically significant disorder (including psychiatric),
condition or disease that would pose a risk to subject safety or interfere with the
study evaluation, procedures or completion;

- Recent or on-going infection(s)

- Underlying condition(s) that predisposes the subject to infections

- History of malignancy of any type

- Additional exclusion criteria apply

Part B only - Crohn's Subjects:

- History or evidence of a clinically significant disorder (including psychiatric),
condition or disease that would pose a risk to subject safety or interfere with the
study evaluation, procedures or completion;

- Recent or on-going infection(s)

- Underlying condition(s) that predisposes the subject to infections

- History of malignancy of any type

- Additional exclusion criteria apply