Weekly IV Topotecan and Cisplatin With Radiation in Cervical Carcinoma
| Status: | Completed |
|---|---|
| Conditions: | Cervical Cancer, Cancer, Cancer, Women's Studies |
| Therapuetic Areas: | Oncology, Reproductive |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/7/2018 |
| Start Date: | January 2004 |
| End Date: | December 17, 2007 |
A Pilot Study of Weekly IV Topotecan and Cisplatin With Concurrent Pelvic Radiation in the Treatment of Stages IB2 - IVA Cervical Carcinoma
There will be approximately 14,000 new patients with invasive cervical cancer diagnosed in
the United States in 2003 with about 4,000 deaths from this disease. This accounts for
approximately 17% of all deaths due to gynecologic cancers. Radiation has been the primary
treatment modality for locoregionally advanced cervical cancer. Recent trials of concomitant
systemic cisplatin chemotherapy and radiation have shown high response rates (RR) with
improvements in durable remissions and overall survival. Though the incidence and mortality
in the U.S. dropped steadily from years 1940 to 2000, there has recently been a plateau,
arresting the decline. With the routine addition of systemic Cisplatin (CDDP) chemotherapy to
local regional radiation, mortality from advanced cervical cancer in the United States is
expected to further decrease. However, further advances in this disease are needed.
the United States in 2003 with about 4,000 deaths from this disease. This accounts for
approximately 17% of all deaths due to gynecologic cancers. Radiation has been the primary
treatment modality for locoregionally advanced cervical cancer. Recent trials of concomitant
systemic cisplatin chemotherapy and radiation have shown high response rates (RR) with
improvements in durable remissions and overall survival. Though the incidence and mortality
in the U.S. dropped steadily from years 1940 to 2000, there has recently been a plateau,
arresting the decline. With the routine addition of systemic Cisplatin (CDDP) chemotherapy to
local regional radiation, mortality from advanced cervical cancer in the United States is
expected to further decrease. However, further advances in this disease are needed.
All eligible patients with invasive squamous cell, adenocarcinoma, or adenosquamous carcinoma
of the cervix, Stages I-B2, II-B, III-B, and IV-A, will experience clinical staging as
permitted by FIGO staging criteria.
Primary Objective:
Feasibility and toxicity of administering weekly Topotecan among patients with carcinoma of
the cervix receiving concurrent pelvic radiation and Cisplatin.
Secondary Objective(s):
To assess the efficacy of administering weekly Topotecan to patients with carcinoma of the
cervix receiving concurrent pelvic radiation and Cisplatin on:
- progression-free survival,
- overall survival, and
- local control
Statistic This is a feasibility study. A two phase accrual will be utilized. If none or 1 of
the 6 patients in the first Stage of accrual finish the prescribed therapy in over 8 weeks,
then the second Stage of accrual (an additional 6 patients) will increase the Topotecan dose
to 3 mg//m2 on days 1, 8, 15, 22, 29 and once during parametrial boost (6 cycles). If 2 or 3
of the patients in the first stage of accrual finish the prescribed therapy in over 8 weeks,
the dose of the Topotecan will remain the same in the second Phase of accrual. If 4 or more
of the patients in the first stage of accrual finish the prescribed therapy in over 8 weeks,
there will be no second phase of accrual.
of the cervix, Stages I-B2, II-B, III-B, and IV-A, will experience clinical staging as
permitted by FIGO staging criteria.
Primary Objective:
Feasibility and toxicity of administering weekly Topotecan among patients with carcinoma of
the cervix receiving concurrent pelvic radiation and Cisplatin.
Secondary Objective(s):
To assess the efficacy of administering weekly Topotecan to patients with carcinoma of the
cervix receiving concurrent pelvic radiation and Cisplatin on:
- progression-free survival,
- overall survival, and
- local control
Statistic This is a feasibility study. A two phase accrual will be utilized. If none or 1 of
the 6 patients in the first Stage of accrual finish the prescribed therapy in over 8 weeks,
then the second Stage of accrual (an additional 6 patients) will increase the Topotecan dose
to 3 mg//m2 on days 1, 8, 15, 22, 29 and once during parametrial boost (6 cycles). If 2 or 3
of the patients in the first stage of accrual finish the prescribed therapy in over 8 weeks,
the dose of the Topotecan will remain the same in the second Phase of accrual. If 4 or more
of the patients in the first stage of accrual finish the prescribed therapy in over 8 weeks,
there will be no second phase of accrual.
Inclusion Criteria:
1. Patients with primary, previously untreated, histologically confirmed invasive
squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma of the uterine
cervix, Stage I-2, II-B, III-B, IV-A.
2. Patients with negative, non-suspicious para-aortic nodes determined by lymphangiogram,
CT, MRI or lymphadenectomy.
3. Patients with adequate bone marrow function: ANC greater than or equal to 1,500/mcl,
platelets greater than or equal to 100,000/mcl, and Hemoglobin > 10 mg/dl.
4. Patients with adequate renal function: Creatinine equal to or less than 1.5 mg%.
5. Patients with adequate hepatic function: Bilirubin less than or equal to 1.5 x normal
and SGOT and Alkaline phosphatase less than or equal to 3 x normal.
6. Patients who have signed an approved informed consent.
7. Patients with GOG Performance Status of 0, 1, 2, or 3.
8. Patients of childbearing potential must have a negative serum pregnancy test and use
an effective form of contraception.
9. Patients who are suitable for treatment with radical intent using concurrent cisplatin
and pelvic radiation.
Exclusion Criteria:
1. Patients who cannot be or have not been adequately clinically staged.
2. Patients with lower one-third vaginal involvement.
3. Patients with septicemia or severe infection.
4. Patients with circumstances that will not permit completion of the study or required
follow-up.
5. Patients with other invasive malignancies, with the exception of non-melanoma skin
cancer, who had (or have) any evidence of the other cancer present within the last 5
years or whose previous cancer treatment contraindicates this protocol therapy.
6. Patients with carcinoma of the cervical stump.
7. Patients who are lactating or pregnant.
We found this trial at
1
site
Orange, California 92868
Principal Investigator: Bradley Monk, MD
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