Low Dose Ketamine Study on Opioid Tolerance and Hyperalgesia
| Status: | Completed |
|---|---|
| Conditions: | Orthopedic, Pain |
| Therapuetic Areas: | Musculoskeletal, Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 10 - 18 |
| Updated: | 4/21/2016 |
| Start Date: | January 2010 |
| End Date: | September 2012 |
Modulation of μ Opioid Receptor Mediated Analgesia, Tolerance and Hyperalgesia in Children and Adolescents
The purpose of this study is to:
1. Establish whether ketamine can decrease opioid consumption and modulate the onset of
opioid tolerance and prevent opioid-induced hyperalgesia in pediatric subjects, ages 10
years to 18 years, undergoing posterior spinal fusion and instrumentation.
1. Establish whether ketamine can decrease opioid consumption and modulate the onset of
opioid tolerance and prevent opioid-induced hyperalgesia in pediatric subjects, ages 10
years to 18 years, undergoing posterior spinal fusion and instrumentation.
Inclusion Criteria:
1. The subject is 10 to 18 years of age
2. The subject's American Society of Anesthesiologists physical status is ASA 1, 2 or 3
(see appendix I)
3. The subject is scheduled for elective posterior spinal fusion and instrumentation.
4. The subject's parent/legally authorized guardian has given written informed consent
to participate
Exclusion Criteria:
1. The subject has a history or a family (parent or sibling) history of malignant
hyperthermia
2. The subject is pregnant or nursing.
3. The subject has known significant renal disorders determined by medical history,
physical examination or laboratory tests
4. The subject has a known or suspected allergy to morphine, remifentanil or ketamine
5. The subject is an ASA classification of 4 or greater (See Appendix I)
6. The subject is scheduled for a surgical sub-procedure (i.e. anterior spinal fusion)
7. The subject is unable to self-administer morphine using patient-controlled analgesia
(PCA) pump
8. The subject had a recent opioid exposure (within 1 month of surgery)
9. The subject is obese (body mass index >30kg/m2)
10. The subject is planned for elective postoperative ventilation
11. The subject has a known ocular disease not permitting pupillometric examination
12. The subject has used any investigation products in the past 30 days
We found this trial at
1
site
111 Michigan Ave NW
Washington, District of Columbia
Washington, District of Columbia
(202) 476-5000
Childrens National Medical Center As the nation’s children’s hospital, the mission of Children’s National Medical...
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