High-dose Periop Statins for Prevention of DVT
| Status: | Completed |
|---|---|
| Conditions: | Cervical Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 12/2/2016 |
| Start Date: | November 2005 |
| End Date: | August 2007 |
High-dose Statin Therapy in the Perioperative Period and DVT Prevention.
This study is designed to determine if the use of atorvastatin (Lipitor), a member of the
HMG coA reductase inhibitor class of drugs referred to as statins, will reduce inflammatory
responses and deep vein thrombosis formation when given in high doses in the perioperative
period.
HMG coA reductase inhibitor class of drugs referred to as statins, will reduce inflammatory
responses and deep vein thrombosis formation when given in high doses in the perioperative
period.
Inclusion Criteria:
- gynecologic tumor scheduled for resection
Exclusion Criteria:
- prior reaction to statins
- renal insufficiency
- liver disease
- h/o alcoholism
- prior h/o DVT or hypercoagulability
- concurrent medications that significantly affect cytochrome P450 3A4
- breast feeding or pregnancy
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