Exercise Versus Diet in the Treatment of Nonalcoholic Fatty Liver Disease
| Status: | Completed |
|---|---|
| Conditions: | Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - 60 |
| Updated: | 4/2/2016 |
| Start Date: | October 2010 |
| End Date: | October 2013 |
| Contact: | Abhishek Choudhary, MD |
| Email: | choudharya@health.missouri.edu |
| Phone: | 573 882 7349 |
The central hypothesis of this proposal is that a reduction in hepatic mitochondrial
function is the main pathophysiology behind NAFLD (Non-Alcoholic Fatty Liver Disease) and
NASH (Non alcoholic steatohepatitis). The investigators further hypothesize that lifestyle
modifications through aerobic exercise training without weight loss or diet-induced weight
loss are effective in reducing NAFLD parameters by improving hepatic mitochondrial content
and function in human subjects.
The investigators propose a randomized, controlled human clinical trial to compare the
effects of aerobic exercise training (without weight loss) versus diet-induced weight loss
(without exercise) in individuals who have NAFLD or liver biopsy-confirmed NASH
function is the main pathophysiology behind NAFLD (Non-Alcoholic Fatty Liver Disease) and
NASH (Non alcoholic steatohepatitis). The investigators further hypothesize that lifestyle
modifications through aerobic exercise training without weight loss or diet-induced weight
loss are effective in reducing NAFLD parameters by improving hepatic mitochondrial content
and function in human subjects.
The investigators propose a randomized, controlled human clinical trial to compare the
effects of aerobic exercise training (without weight loss) versus diet-induced weight loss
(without exercise) in individuals who have NAFLD or liver biopsy-confirmed NASH
Fatty Liver Disease) and NASH (Non alcoholic steatohepatitis). The investigators further
hypothesize that lifestyle modifications through aerobic exercise training without weight
loss or diet-induced weight loss are effective in reducing NAFLD parameters by improving
hepatic mitochondrial content and function in human subjects.
The investigators propose a randomized, controlled human clinical trial to compare the
effects of aerobic exercise training (without weight loss) versus diet-induced weight loss
(without exercise) in individuals who have NAFLD or liver biopsy-confirmed NASH
hypothesize that lifestyle modifications through aerobic exercise training without weight
loss or diet-induced weight loss are effective in reducing NAFLD parameters by improving
hepatic mitochondrial content and function in human subjects.
The investigators propose a randomized, controlled human clinical trial to compare the
effects of aerobic exercise training (without weight loss) versus diet-induced weight loss
(without exercise) in individuals who have NAFLD or liver biopsy-confirmed NASH
Inclusion Criteria:
- sedentary individual between
- age group 18-60 years old
- elevated Liver Function Tests (LFT's) with fatty liver on ultrasound and biopsy
proven NASH
Exclusion Criteria:
- significant history of alcohol consumption > 20 gm/day (> 2 drinks / day)
- evidence of other causes of hepatitis including positive screening B & C, autoimmune
hepatitis, hemochromatosis, celiac disease, Wilson's disease, alpha 1 antitrypsin
deficiency or medication-induced hepatitis
- Subjects with planned exercise > 30-60 minutes per week
- BMI < 25 or > 44 kg/m2
- clinical or biochemical evidence of decompensated liver disease, advanced cardiac or
renal disease
- changes in last 3 months the dose of oral hypoglycemic medication and statin,
- positive stress test
- pregnant women
- demented individuals who cannot give consent
We found this trial at
1
site
Click here to add this to my saved trials
