Safety Study of Analgesia After Craniotomy Surgery With End Tidal CO2 Monitoring
| Status: | Recruiting |
|---|---|
| Conditions: | Chronic Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 4/2/2016 |
| Start Date: | May 2010 |
| End Date: | May 2016 |
| Contact: | Athir Morad, MD |
| Email: | morada@jhmi.edu |
| Phone: | 410-955-7461 |
Post Craniotomy Analgesia Safety Monitoring With ET CO2
This research is being done to compare two methods of giving fentanyl, a narcotic often
given to patients following brain surgery and determine if one method has more side effects
than the other. Both of these methods are available in the postoperative treatment of pain.
This research also is being done to determine if patients receiving narcotic pain medicine
will benefit from additional monitoring of carbon dioxide levels. Since narcotic pain
medicines can slow down breathing, we want to see if measuring exhaled carbon dioxide levels
will help identify a slower breathing rate and improve safety.
given to patients following brain surgery and determine if one method has more side effects
than the other. Both of these methods are available in the postoperative treatment of pain.
This research also is being done to determine if patients receiving narcotic pain medicine
will benefit from additional monitoring of carbon dioxide levels. Since narcotic pain
medicines can slow down breathing, we want to see if measuring exhaled carbon dioxide levels
will help identify a slower breathing rate and improve safety.
See brief summary
Inclusion Criteria:
- Adult male and female, English speaking patients undergoing supratentorial craniotomy
for tumor under general anesthesia at the Johns Hopkins Hospital will be eligible for
this study.
Exclusion Criteria:
- pregnant women
- patients with post operative neurological changes
- patients who remain intubated post-operatively
- patients who require the use of concomitant administration of sedatives
- patients who are unable to initiate a PCA bolus
- patients who are unable to communicate verbally
- patients who are allergic to fentanyl
- patients who have a history of narcotic abuse
- patients who have a history of chronic pain requiring opioids
- patients who have been in any investigational drug trial within 1 month of the
treatment day
- patients who have chronic respiratory insufficiency
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