Evaluating Treatment Response in Laryngo-Pharyngeal Reflux
| Status: | Completed |
|---|---|
| Conditions: | Gastroesophageal Reflux Disease |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/2/2016 |
| Start Date: | May 2011 |
| End Date: | April 2012 |
| Contact: | Brant K Oelschalger, MD |
| Email: | brant@uw.edu |
| Phone: | 206-543-3518 |
Although laryno-pharyngeal reflux (LPR) and gastroesophageal reflux disease (GERD) differ in
symptoms and treatment, they are diagnosed by the same standard 24-hour pH monitoring system
which measures liquid reflux in the esophagus. The investigators are evaluating a new
24-hour pharyngeal pH monitoring system by Restech which can measure acid exposure in the
airway and can be used specifically for LPR diagnosis. The purpose of this study is to
determine whether the Restech device is more effective than standard pH monitoring in
predicting the response to proton pump inhibitor (PPI) acid suppression therapy using
Dexlansoprazole in patients with symptoms and/or manifestations of LPR.
symptoms and treatment, they are diagnosed by the same standard 24-hour pH monitoring system
which measures liquid reflux in the esophagus. The investigators are evaluating a new
24-hour pharyngeal pH monitoring system by Restech which can measure acid exposure in the
airway and can be used specifically for LPR diagnosis. The purpose of this study is to
determine whether the Restech device is more effective than standard pH monitoring in
predicting the response to proton pump inhibitor (PPI) acid suppression therapy using
Dexlansoprazole in patients with symptoms and/or manifestations of LPR.
Inclusion Criteria:
- Age 18 years old or above
- Have a clinical diagnosis of LPR
- Able and willing to provide consent
Exclusion Criteria:
- History of any previous anti-reflux operation or procedure
- History of pharyngeal or laryngeal surgery
- History of larngeal or hypolaryngeal neoplasm
- Allergy or significant adverse reaction to PPI
- Patient on PPI therapy within 4 weeks prior to enrollment
- A cumulative history of PPI therapy equal to or greater than 3 months
- History of noncompliance with medication or study protocols
- Enrolled in another clinical trial using investigational medications
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