Acupuncture and Post-Surgical Wound Healing
| Status: | Completed |
|---|---|
| Conditions: | Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 7/16/2013 |
| Start Date: | March 2005 |
| End Date: | April 2007 |
| Contact: | Harriet W Hopf, MD |
| Email: | harriet.hopf@hsc.utah.edu |
| Phone: | (801) 205-1013 |
Acupuncture and Post-Surgical Wound Healing in Coronary Artery Bypass Graft Patients Undergoing Open Saphenous Vein Graft Harvest
The purpose of this study is to determine if acupuncture improves wound healing. Since we,
the investigators at the University of California, San Francisco, know that how much oxygen
is delivered to tissue is the best predictor of how well a wound will heal, we are measuring
changes in tissue oxygen of wounds before and after acupuncture treatments. We are focusing
on the leg wounds of coronary artery bypass graft (CABG) patients who have their saphenous
veins harvested in an open fashion since this is a fairly well controlled patient model.
This is a prospective, randomized, controlled pilot study of the effects of acupuncture on
surgical site complications in patients undergoing coronary artery bypass grafting. The
past forty years of research in the UCSF Wound Healing Laboratory have solidified the
following observations:
1. without adequate oxygen delivery, many processes of wound healing cannot proceed
normally, particularly resistance to infection, collagen deposition, angiogenesis, and
inflammation; and
2. hypoxic conditions, unfortunately, are common in chronic and acute wounds, and often
result from subcutaneous vasoconstriction.
Sympathetic nervous system (SNS) activators and other vasoconstrictors have been shown to
produce wound hypoxia. Activation of the SNS by any means, including pain and anxiety,
causes vasoconstriction and impairs oxygen delivery. Simple means that limit SNS activity
have been shown to increase perfusion and oxygen tension, and thereby facilitate wound
healing. Many preliminary studies have shown that acupuncture decreases SNS activation,
pain, and anxiety. In addition, there is evidence that acupuncture enhances circulation of
blood. We therefore hypothesize that acupuncture will facilitate wound healing. We aim to
quantify changes in anxiety, pain, stress hormones, and perfusion and oxygenation induced by
these interventions, as well as wound healing outcomes, including infection and other wound
complications.
Inclusion Criteria:
- Adults (age > 18)
- Males/females
- All races
- Elective/urgent CABG
- Open saphenous vein graft harvest
- University of California, San Francisco, and additional approved hospital sites
Exclusion Criteria:
Pre-operative
- Emergent CABG, valves
- History of peripheral vascular surgery, amputation, severe peripheral neuropathy,
immunocompromise, or end-stage renal disease requiring hemodialysis
Post-operative
- Postoperative day 1 (POD1) hemodynamic instability
- ≥ 4u packed red blood cells transfusion (PRBC)/8 hours, CT > 200cc/hour 3 hours, > 2
pressors
- Prolonged intubation (> POD1)
- Altered mental status
We found this trial at
1
site
500 Parnassus Ave
San Francisco, California 94110
San Francisco, California 94110
(415) 476-9000
University of California, San Francisco UCSF's clinical enterprise is recognized nationally for its leading health...
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