Spine Quantitative Computed Tomography (QCT) for the Assessment of Osteoporosis on Children



Status:Completed
Conditions:Lupus, Osteoporosis
Therapuetic Areas:Immunology / Infectious Diseases, Rheumatology
Healthy:No
Age Range:5 - 21
Updated:10/5/2017
Start Date:October 2010
End Date:June 2017

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Trial Summary
Trial Overview
Inclusion Criteria
The purpose of this study is to compare healthy children to children who have systemic lupus
erythematosus (SLE). SLE is a childhood disease that has high risk for low bone mass and
vertebral compression fractures.

The purpose of this research study is to measure bone mass in children with SLE using
different measurement techniques. Children with chronic illnesses are at risk of bone
fragility. This is important because bone fragility can result in childhood fractures
especially children with SLE. Therefore better diagnosis technique can lead to better
management of bone health.

Inclusion Criteria:

- For SLE subjects: Subjects age 5-21 drawn from rheumatology clinic at Children's
Hospital of Philadelphia diagnosed with SLE for at least 1 month. Also subjects with
no known vertebral compression fracture of L2.

- For Control subjects: Subjects age 5-21. Controls will be a 50% male/female.

Exclusion Criteria:

- For SLE subjects: Subjects with SLE will be excluded if they have conditions or drug
exposure unrelated to SLE and known to impact growth or bone health.

- For Control subjects: Chronic disease or syndrome known to affect growth or bone
health, prematurity (<37 weeks gestation), or use of any medication known to affect
growth.
We found this trial at
1
site
Children's Hospital of Philadelphia
South 34th Street
Philadelphia, Pennsylvania 19104
 215-590-1000
Children's Hospital of Philadelphia Since its start in 1855 as the nation's first hospital devoted...
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