Impact of Subcutaneous Abatacept in Rheumatoid Arthritis Assessing Inhibition of Structural Damage

This is an open-label study of the efficacy of subcutaneous (SC) Abatacept to inhibit
progression of structural joint damage in patients with active rheumatoid arthritis (RA)
receiving MTX and have inadequate disease control (defined as an ESR based DAS28 ≥ 3.2 AND ≥
6 swollen and ≥ 6 tender joints). The study consists of a screening period (Days -21 to
-7), a baseline visit (Days -20 to -1), and a treatment Period (open label Abatacept 125 mg
SC for 24 weeks). All the visits may occur at the indicated week +/- 2 days. The last
efficacy assessments are to be conducted at Week 24 and subjects are to be contacted by
telephone for a safety follow-up 2 months after the final study agent has been administered.

The maximum length of the study is 35 weeks, which includes the 2-week screening period,
1-week baseline period, 24-week open label treatment, and 8-week follow-up period. Eligible
subjects are to continue their current MTX treatment regimen, a stable dose of at least
15mg/week, during the entire length of the study (24 weeks). At Day 0, patients who meet
inclusion criteria, will be dosed from Day 0 to Week 24 with Abatacept 125 mg SC injection.

Subjects are to self-administer SC study agent at Weeks 5, 6, 7, 9, 10, 11, 13, 14, 15, 17,
18, 19, 21, 22, and 23 and are not required to return to the study site at these weeks. All
other visits, SC study agent is to be administered while the subject is at the study site.

Inclusion Criteria:

1. Subjects currently experiencing active moderate to severe RA according to the revised
1987 ACR criteria for the diagnosis of RA at screening. The ESR-based DAS 28 must be
equal or greater than 3.2

2. MTX inadequate responders with moderate to severe RA. Subjects currently receiving
MTX for at least 12 weeks and who have received MTX at a stable dose (≥15mg/week) for
at least 6 weeks prior to treatment (Day 0). They must be biologic drug naive

3. All subjects must receive at least 5 mg oral folic acid weekly.

4. At screening active RA as defined by ≥ 6 swollen joints and ≥ 6 tender joints with
erythrocyte sedimentation rate (ESR) ≥ 28 mm/h.

5. Subjects must be seropositive with documented rheumatoid factor (RF) or anti-cyclic
citrullinated peptide (anti CCP) positivity. If a documented history of RF or anti
CCP positivity is not available, RF and anti CCP titers will be obtained at screening

6. MRI evidence of at least one joint with osteitis or erosion attributable to RA as
determined by an MRI musculoskeletal radiologist. Any joint of the dominant hand or
wrist can be considered with the exception of distal interphalangeal joints of the
hands.

7. If subjects are receiving an oral corticosteroid, the dose must be ≤10 mg/day
prednisone (or equivalent) and stable for at least 28 days prior to treatment (Day
0).

8. Subjects able and willing to give written informed consent and comply with the
requirements of the study protocol. Informed consent must be obtained prior to any
study-related procedures.

A copy of the signed informed consent form must be given to the subject

9. Subjects must be willing to self-inject or allow a caregiver to administer the
subcutaneous injection

Exclusion Criteria:

1. Major surgery (including joint surgery) within 8 weeks prior to screening or planned
major surgery within 6 months following randomization

2. Rheumatic autoimmune disease other than RA, including systemic lupus erythematosus
(SLE), mixed connective tissue disease (MCTD), scleroderma, polymyositis, or
significant systemic involvement secondary to RA (vasculitis, pulmonary fibrosis or
Felty's syndrome). Prior history of or current inflammatory joint disease other than
RA (gout, Lyme disease, seronegative spondyloarthropathy including reactive arthritis
and psoriatic arthritis)

3. Functional class IV as defined by the ACR Classification of Functional Status in RA

4. Current treatment with any traditional DMARDs other than MTX within 4 weeks before
the screening visit

5. Treatment with any investigational agent within 4 weeks (or 5 half-lives of
investigational agent, whichever is longer) before screening

6. Exposure to any Biologic Response Modifying Agent

7. Intra Articular or parenteral corticosteroids within 6 weeks prior to screening

8. Immunization with live vaccine within 3 months prior to enrollment and a need for a
live vaccine during the study

9. Subjects who have a metal device where the use of MRI is contraindicated (e.g.,any
type of electronic, mechanical, or magnetic implant; cardiac pacemaker, aneurysm
clip; implanted cardioverter defibrillator; or a cochlear implant). Subjects who have
a potential ferromagnetic foreign body (metal shavings, metal slivers, other metal
objects) for which they have sought medical attention

10. Exclusionary laboratory: Serum creatinine >2 mg/dL, ALT or AST > 2.0 x ULN, total
bilirubin > 2.0 x ULN, platelet count <100 x 109 /L, hemoglobin < 8.5 g/dL, WBC count
< 1,000/mm3 , absolute neutrophil count < 1,000/ mm3, absolute lymphocyte count <
500/mm3, positive HBsAg or HCV antibody, or positive HIV test.

11. Pregnant women or nursing mothers

12. Females of child bearing potential who are not using reliable means of contraception

13. Evidence of serious uncontrolled concomitant cardiovascular, nervous system,
pulmonary, renal, hepatic, endocrine or GI disease

14. Uncontrolled disease states, such as asthma, psoriasis, or inflammatory bowel
syndrome, where flares are commonly treated with corticosteroids

15. Known active current or history of recurrent bacterial, viral, fungal, mycobacterial,
or other infections such as atypical mycobacterial disease, hepatitis B and C, HIV,
herpes zoster, or any major episode of infection requiring hospitalization or
treatment with IV antibiotics within 4 weeks of screening or oral antibiotics within
2 weeks prior to screening.

16. A history of active TB within the last 3 years even if it was treated. A history of
active TB greater than 3 years ago unless there is documentation that the prior
anti-TB treatment was appropriate in duration and type. A positive PPD skin test (≥5
mm) or positive QuantiFERON-TB Gold serum test without appropriate prophylaxis (at
least 1 month of the planned local guidelines treatment regimen)

17. Any malignancy except for skin cancer (basal cell or squamous cell) diagnosed within
the previous 5 years

18. History of alcohol, drug, or chemical abuse

19. Neuropathies or other painful conditions that might interfere with pain evaluation